OR8A1_HUMAN
ID OR8A1_HUMAN Reviewed; 326 AA.
AC Q8NGG7; Q6IEW7; Q96RC6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 8A1;
DE AltName: Full=OST025;
DE AltName: Full=Olfactory receptor OR11-318;
GN Name=OR8A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-299.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06052.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8A1";
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DR EMBL; AB065833; BAC06052.1; ALT_INIT; Genomic_DNA.
DR EMBL; AP000916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67586.1; -; Genomic_DNA.
DR EMBL; BC137194; AAI37195.1; -; mRNA.
DR EMBL; BC137197; AAI37198.1; -; mRNA.
DR EMBL; AF399512; AAK94997.1; -; Genomic_DNA.
DR EMBL; BK004495; DAA04893.1; -; Genomic_DNA.
DR RefSeq; NP_001005194.1; NM_001005194.1.
DR AlphaFoldDB; Q8NGG7; -.
DR SMR; Q8NGG7; -.
DR BioGRID; 133486; 2.
DR STRING; 9606.ENSP00000284287; -.
DR GlyGen; Q8NGG7; 1 site.
DR PhosphoSitePlus; Q8NGG7; -.
DR BioMuta; OR8A1; -.
DR DMDM; 212276454; -.
DR MassIVE; Q8NGG7; -.
DR PaxDb; Q8NGG7; -.
DR PRIDE; Q8NGG7; -.
DR Antibodypedia; 56821; 61 antibodies from 15 providers.
DR DNASU; 390275; -.
DR Ensembl; ENST00000642111.1; ENSP00000492999.1; ENSG00000196119.8.
DR GeneID; 390275; -.
DR KEGG; hsa:390275; -.
DR UCSC; uc010san.3; human.
DR CTD; 390275; -.
DR DisGeNET; 390275; -.
DR GeneCards; OR8A1; -.
DR HGNC; HGNC:8469; OR8A1.
DR HPA; ENSG00000196119; Low tissue specificity.
DR neXtProt; NX_Q8NGG7; -.
DR OpenTargets; ENSG00000196119; -.
DR PharmGKB; PA32744; -.
DR VEuPathDB; HostDB:ENSG00000196119; -.
DR eggNOG; ENOG502T9KS; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG7; -.
DR OrthoDB; 936657at2759; -.
DR PhylomeDB; Q8NGG7; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390275; 65 hits in 677 CRISPR screens.
DR GeneWiki; OR8A1; -.
DR GenomeRNAi; 390275; -.
DR Pharos; Q8NGG7; Tdark.
DR PRO; PR:Q8NGG7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG7; protein.
DR Bgee; ENSG00000196119; Expressed in calcaneal tendon and 13 other tissues.
DR ExpressionAtlas; Q8NGG7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 8A1"
FT /id="PRO_0000150653"
FT TOPO_DOM 1..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 133
FT /note="T -> R (in dbSNP:rs55861866)"
FT /id="VAR_062057"
FT VARIANT 218
FT /note="S -> L (in dbSNP:rs12792184)"
FT /id="VAR_053238"
SQ SEQUENCE 326 AA; 36388 MW; B939AB0E17796279 CRC64;
MGFLSPMHPC RPPTQRRMAA GNHSTVTEFI LKGLTKRADL QLPLFLLFLG IYLVTIVGNL
GMITLICLNS QLHTPMYYFL SNLSLMDLCY SSVITPKMLV NFVSEKNIIS YAGCMSQLYF
FLVFVIAECY MLTVMAYDRY VAICHPLLYN IIMSHHTCLL LVAVVYAIGL IGSTIETGLM
LKLPYCEHLI SHYFCDILPL MKLSCSSTYD VEMTVFFSAG FNIIVTSLTV LVSYTFILSS
ILGISTTEGR SKAFSTCSSH LAAVGMFYGS TAFMYLKPST ISSLTQENVA SVFYTTVIPM
LNPLIYSLRN KEVKAAVQKT LRGKLF
