OR8B2_HUMAN
ID OR8B2_HUMAN Reviewed; 313 AA.
AC Q96RD0; Q8NGH2;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Olfactory receptor 8B2;
DE AltName: Full=Olfactory receptor OR11-309;
GN Name=OR8B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B2";
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DR EMBL; AB065826; BAC06045.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67580.1; -; Genomic_DNA.
DR EMBL; AF399508; AAK94993.1; -; Genomic_DNA.
DR EMBL; BK004500; DAA04898.1; -; Genomic_DNA.
DR CCDS; CCDS31708.1; -.
DR RefSeq; NP_001005468.1; NM_001005468.1.
DR RefSeq; XP_016873024.1; XM_017017535.1.
DR RefSeq; XP_016873025.1; XM_017017536.1.
DR AlphaFoldDB; Q96RD0; -.
DR SMR; Q96RD0; -.
DR BioGRID; 117761; 1.
DR STRING; 9606.ENSP00000364152; -.
DR GlyGen; Q96RD0; 1 site.
DR BioMuta; OR8B2; -.
DR DMDM; 229462942; -.
DR MassIVE; Q96RD0; -.
DR PaxDb; Q96RD0; -.
DR PRIDE; Q96RD0; -.
DR Antibodypedia; 78415; 18 antibodies from 10 providers.
DR DNASU; 26595; -.
DR Ensembl; ENST00000641451.2; ENSP00000493235.1; ENSG00000284680.3.
DR GeneID; 26595; -.
DR KEGG; hsa:26595; -.
DR MANE-Select; ENST00000641451.2; ENSP00000493235.1; NM_001005468.2; NP_001005468.1.
DR UCSC; uc010sai.3; human.
DR CTD; 26595; -.
DR GeneCards; OR8B2; -.
DR HGNC; HGNC:8471; OR8B2.
DR HPA; ENSG00000284680; Tissue enhanced (testis).
DR neXtProt; NX_Q96RD0; -.
DR PharmGKB; PA32750; -.
DR VEuPathDB; HostDB:ENSG00000284680; -.
DR eggNOG; ENOG502RTZT; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q96RD0; -.
DR OMA; FQQPFFF; -.
DR OrthoDB; 954097at2759; -.
DR PhylomeDB; Q96RD0; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q96RD0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26595; 7 hits in 584 CRISPR screens.
DR GeneWiki; OR8B2; -.
DR GenomeRNAi; 26595; -.
DR Pharos; Q96RD0; Tdark.
DR PRO; PR:Q96RD0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96RD0; protein.
DR Bgee; ENSG00000284680; Expressed in left testis and 1 other tissue.
DR ExpressionAtlas; Q96RD0; baseline and differential.
DR Genevisible; Q96RD0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 8B2"
FT /id="PRO_0000150654"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="H -> R (in dbSNP:rs28373946)"
FT /id="VAR_062058"
FT VARIANT 27
FT /note="L -> F (in dbSNP:rs530740)"
FT /id="VAR_055147"
FT VARIANT 164
FT /note="L -> F (in dbSNP:rs886202)"
FT /id="VAR_060011"
FT VARIANT 273
FT /note="S -> F (in dbSNP:rs503220)"
FT /id="VAR_062059"
SQ SEQUENCE 313 AA; 35272 MW; 6FA6C2FC8DD4BE5F CRC64;
MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY
YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY
DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD
ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST
CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
RKALIKIQRR NIF
