OR8B3_HUMAN
ID OR8B3_HUMAN Reviewed; 313 AA.
AC Q8NGG8; Q6IFQ8; Q8NGH1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 8B3;
DE AltName: Full=Olfactory receptor OR11-311;
GN Name=OR8B3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-20 AND ILE-114.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION, AND VARIANT ARG-20.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B3";
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DR EMBL; AB065827; BAC06046.1; -; Genomic_DNA.
DR EMBL; AB065830; BAC06049.1; -; Genomic_DNA.
DR EMBL; AC002556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004204; DAA04602.1; -; Genomic_DNA.
DR CCDS; CCDS31709.1; -.
DR RefSeq; NP_001005467.1; NM_001005467.1.
DR RefSeq; XP_016873205.1; XM_017017716.1.
DR RefSeq; XP_016873206.1; XM_017017717.1.
DR RefSeq; XP_016873207.1; XM_017017718.1.
DR AlphaFoldDB; Q8NGG8; -.
DR SMR; Q8NGG8; -.
DR STRING; 9606.ENSP00000346611; -.
DR GlyGen; Q8NGG8; 1 site.
DR PhosphoSitePlus; Q8NGG8; -.
DR BioMuta; OR8B3; -.
DR DMDM; 311033419; -.
DR MassIVE; Q8NGG8; -.
DR PaxDb; Q8NGG8; -.
DR PRIDE; Q8NGG8; -.
DR Antibodypedia; 78416; 19 antibodies from 11 providers.
DR DNASU; 390271; -.
DR Ensembl; ENST00000641139.1; ENSP00000493120.1; ENSG00000284609.2.
DR GeneID; 390271; -.
DR KEGG; hsa:390271; -.
DR MANE-Select; ENST00000641139.1; ENSP00000493120.1; NM_001005467.2; NP_001005467.1.
DR UCSC; uc010saj.3; human.
DR CTD; 390271; -.
DR DisGeNET; 390271; -.
DR GeneCards; OR8B3; -.
DR HGNC; HGNC:8472; OR8B3.
DR HPA; ENSG00000284609; Not detected.
DR neXtProt; NX_Q8NGG8; -.
DR PharmGKB; PA32751; -.
DR VEuPathDB; HostDB:ENSG00000284609; -.
DR eggNOG; ENOG502RTZT; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG8; -.
DR OMA; NIMVPSF; -.
DR OrthoDB; 954097at2759; -.
DR PhylomeDB; Q8NGG8; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG8; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390271; 8 hits in 582 CRISPR screens.
DR GenomeRNAi; 390271; -.
DR Pharos; Q8NGG8; Tdark.
DR PRO; PR:Q8NGG8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG8; protein.
DR Bgee; ENSG00000284609; Expressed in testis and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 8B3"
FT /id="PRO_0000150655"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="H -> R (in dbSNP:rs507335)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_047145"
FT VARIANT 114
FT /note="M -> I (in dbSNP:rs530992)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_047146"
FT CONFLICT 24
FT /note="Q -> R (in Ref. 1; BAC06046)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="V -> I (in Ref. 1; BAC06046)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35305 MW; 22A778F500EDEABC CRC64;
MLARNNSLVT EFILAGLTDH PEFQQPLFFL FLVVYIVTMV GNLGLIILFG LNSHLHTPMY
YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISYVGCMTQ LFFFLFFVIS ECYMLTSMAY
DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD
ILPLLQLSCT STYVNEVVVL IVVGINIMVP SCTILISYVF IVTSILHIKS TQGRSKAFST
CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
RKALIKIQRR NIF
