OR8B4_HUMAN
ID OR8B4_HUMAN Reviewed; 309 AA.
AC Q96RC9; B2RNF8; Q6IFQ7;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 8B4;
DE AltName: Full=Olfactory receptor OR11-315;
GN Name=OR8B4; Synonyms=OR8B4P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-131; PHE-140 AND
RP ARG-178.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B4";
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DR EMBL; AB065831; BAC06050.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67582.1; -; Genomic_DNA.
DR EMBL; BC136865; AAI36866.1; -; mRNA.
DR EMBL; BC136866; AAI36867.1; -; mRNA.
DR EMBL; AF399509; AAK94994.1; -; Genomic_DNA.
DR EMBL; BK004205; DAA04603.1; -; Genomic_DNA.
DR CCDS; CCDS31710.1; -.
DR RefSeq; NP_001005196.1; NM_001005196.1.
DR AlphaFoldDB; Q96RC9; -.
DR SMR; Q96RC9; -.
DR STRING; 9606.ENSP00000485212; -.
DR GlyGen; Q96RC9; 1 site.
DR BioMuta; OR8B4; -.
DR DMDM; 20532194; -.
DR PaxDb; Q96RC9; -.
DR PeptideAtlas; Q96RC9; -.
DR PRIDE; Q96RC9; -.
DR Antibodypedia; 78417; 118 antibodies from 23 providers.
DR DNASU; 283162; -.
DR Ensembl; ENST00000356130.7; ENSP00000348449.3; ENSG00000280090.3.
DR GeneID; 283162; -.
DR KEGG; hsa:283162; -.
DR MANE-Select; ENST00000356130.7; ENSP00000348449.3; NM_001005196.1; NP_001005196.1.
DR UCSC; uc010sak.2; human.
DR CTD; 283162; -.
DR GeneCards; OR8B4; -.
DR HGNC; HGNC:8473; OR8B4.
DR HPA; ENSG00000280090; Not detected.
DR neXtProt; NX_Q96RC9; -.
DR PharmGKB; PA32752; -.
DR VEuPathDB; HostDB:ENSG00000280090; -.
DR eggNOG; ENOG502RU0N; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q96RC9; -.
DR OMA; SNILCIP; -.
DR OrthoDB; 1063203at2759; -.
DR PhylomeDB; Q96RC9; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q96RC9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283162; 12 hits in 661 CRISPR screens.
DR GeneWiki; OR8B4; -.
DR GenomeRNAi; 283162; -.
DR Pharos; Q96RC9; Tdark.
DR PRO; PR:Q96RC9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96RC9; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 8B4"
FT /id="PRO_0000150656"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 22
FT /note="E -> G (in dbSNP:rs10750270)"
FT /id="VAR_053239"
FT VARIANT 131
FT /note="Y -> H (in dbSNP:rs4057750)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024115"
FT VARIANT 140
FT /note="C -> F (in dbSNP:rs7116575)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053240"
FT VARIANT 178
FT /note="C -> R (in dbSNP:rs4057749)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053241"
SQ SEQUENCE 309 AA; 34404 MW; A187E1685EA59709 CRC64;
MTLRNSSSVT EFILVGLSEQ PELQLPLFLL FLGIYVFTVV GNLGLITLIG INPSLHTPMY
FFLFNLSFID LCYSCVFTPK MLNDFVSESI ISYVGCMTQL FFFCFFVNSE CYVLVSMAYD
RYVAICNPLL YMVTMSPRVC FLLMFGSYVV GFAGAMAHTG SMLRLTFCDS NVIDHYLCDV
LPLLQLSCTS THVSELVFFI VVGVITMLSS ISIVISYALI LSNILCIPSA EGRSKAFSTW
GSHIIAVALF FGSGTFTYLT TSFPGSMNHG RFASVFYTNV VPMLNPSIYS LRNKDDKLAL
GKTLKRVLF
