OR8B8_HUMAN
ID OR8B8_HUMAN Reviewed; 311 AA.
AC Q15620; A1L446; Q96RC8;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Olfactory receptor 8B8;
DE AltName: Full=Olfactory receptor TPCR85;
DE AltName: Full=Olfactory-like receptor JCG8;
GN Name=OR8B8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue and testis.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B8";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF238488; AAL32997.1; -; mRNA.
DR EMBL; AB065832; BAC06051.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67583.1; -; Genomic_DNA.
DR EMBL; BC130393; AAI30394.1; -; mRNA.
DR EMBL; BC130419; AAI30420.1; -; mRNA.
DR EMBL; AF399510; AAK94995.1; -; Genomic_DNA.
DR EMBL; X89675; CAA61822.1; -; mRNA.
DR CCDS; CCDS8446.1; -.
DR PIR; S58007; S58007.
DR RefSeq; NP_036510.1; NM_012378.1.
DR AlphaFoldDB; Q15620; -.
DR SMR; Q15620; -.
DR BioGRID; 117703; 3.
DR STRING; 9606.ENSP00000330280; -.
DR GlyGen; Q15620; 1 site.
DR BioMuta; OR8B8; -.
DR DMDM; 14423794; -.
DR MassIVE; Q15620; -.
DR PaxDb; Q15620; -.
DR PeptideAtlas; Q15620; -.
DR PRIDE; Q15620; -.
DR Antibodypedia; 53986; 70 antibodies from 20 providers.
DR DNASU; 26493; -.
DR Ensembl; ENST00000328064.2; ENSP00000330280.2; ENSG00000197125.3.
DR Ensembl; ENST00000642064.1; ENSP00000493014.1; ENSG00000197125.3.
DR GeneID; 26493; -.
DR KEGG; hsa:26493; -.
DR MANE-Select; ENST00000642064.1; ENSP00000493014.1; NM_012378.2; NP_036510.1.
DR UCSC; uc010sal.3; human.
DR CTD; 26493; -.
DR GeneCards; OR8B8; -.
DR HGNC; HGNC:8477; OR8B8.
DR HPA; ENSG00000197125; Not detected.
DR neXtProt; NX_Q15620; -.
DR OpenTargets; ENSG00000197125; -.
DR PharmGKB; PA32756; -.
DR VEuPathDB; HostDB:ENSG00000197125; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q15620; -.
DR OMA; AMTHTAC; -.
DR OrthoDB; 1077225at2759; -.
DR PhylomeDB; Q15620; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q15620; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26493; 9 hits in 668 CRISPR screens.
DR GeneWiki; OR8B8; -.
DR GenomeRNAi; 26493; -.
DR Pharos; Q15620; Tdark.
DR PRO; PR:Q15620; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q15620; protein.
DR Bgee; ENSG00000197125; Expressed in cardiac atrium and 1 other tissue.
DR ExpressionAtlas; Q15620; baseline and differential.
DR Genevisible; Q15620; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 8B8"
FT /id="PRO_0000150657"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 204
FT /note="G -> S (in Ref. 6; CAA61822)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 34482 MW; 9D8AAC4DA179ABE6 CRC64;
MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR LNSHLHTPMY
FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ LFFFLFFVVS ESFILSAMAY
DRYVAICNPL LYMVTMSPQV CFLLLLGVYG MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD
ILPLLECACT STYVNELVVF VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST
CSSHIIAVSL FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA
LKKILNKNAF S
