OR8BC_HUMAN
ID OR8BC_HUMAN Reviewed; 310 AA.
AC Q8NGG6; B2RNF6; Q6IEW8; Q96RC7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 8B12;
DE AltName: Full=Olfactory receptor OR11-317;
GN Name=OR8B12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B12";
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DR EMBL; AB065834; BAC06053.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67585.1; -; Genomic_DNA.
DR EMBL; BC136863; AAI36864.1; -; mRNA.
DR EMBL; BC136864; AAI36865.1; -; mRNA.
DR EMBL; AF399511; AAK94996.1; -; Genomic_DNA.
DR EMBL; BK004494; DAA04892.1; -; Genomic_DNA.
DR CCDS; CCDS31711.1; -.
DR RefSeq; NP_001005195.1; NM_001005195.1.
DR AlphaFoldDB; Q8NGG6; -.
DR SMR; Q8NGG6; -.
DR STRING; 9606.ENSP00000307159; -.
DR GlyGen; Q8NGG6; 3 sites.
DR iPTMnet; Q8NGG6; -.
DR PhosphoSitePlus; Q8NGG6; -.
DR BioMuta; OR8B12; -.
DR DMDM; 38372689; -.
DR MassIVE; Q8NGG6; -.
DR PaxDb; Q8NGG6; -.
DR PeptideAtlas; Q8NGG6; -.
DR PRIDE; Q8NGG6; -.
DR Antibodypedia; 64024; 59 antibodies from 17 providers.
DR DNASU; 219858; -.
DR Ensembl; ENST00000306842.3; ENSP00000307159.2; ENSG00000170953.4.
DR GeneID; 219858; -.
DR KEGG; hsa:219858; -.
DR MANE-Select; ENST00000306842.3; ENSP00000307159.2; NM_001005195.1; NP_001005195.1.
DR UCSC; uc010sam.3; human.
DR CTD; 219858; -.
DR GeneCards; OR8B12; -.
DR HGNC; HGNC:15307; OR8B12.
DR HPA; ENSG00000170953; Not detected.
DR neXtProt; NX_Q8NGG6; -.
DR PharmGKB; PA32748; -.
DR VEuPathDB; HostDB:ENSG00000170953; -.
DR eggNOG; ENOG502TAH8; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG6; -.
DR OMA; HTGSIMN; -.
DR OrthoDB; 1077225at2759; -.
DR PhylomeDB; Q8NGG6; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219858; 12 hits in 666 CRISPR screens.
DR GeneWiki; OR8B12; -.
DR GenomeRNAi; 219858; -.
DR Pharos; Q8NGG6; Tdark.
DR PRO; PR:Q8NGG6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG6; protein.
DR Bgee; ENSG00000170953; Expressed in left testis and 1 other tissue.
DR ExpressionAtlas; Q8NGG6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 8B12"
FT /id="PRO_0000150658"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34372 MW; 5035D547E91CDB3F CRC64;
MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL NSHLHTPMYF
FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL FFFCFFVVSE SFILSAMAYD
RYVAICNPLL YTVTMSCQVC LLLLLGAYGM GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI
LPLLELSCNS SYMNELVVFI VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC
SSHIIVVSLF FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL
RRTLGRKIFS
