OR8D1_HUMAN
ID OR8D1_HUMAN Reviewed; 308 AA.
AC Q8WZ84; B2RNL4; Q6IEW1; Q8NGH0;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 8D1;
DE AltName: Full=OST004;
DE AltName: Full=Olfactory receptor 8D3;
DE AltName: Full=Olfactory receptor OR11-301;
DE AltName: Full=Olfactory receptor-like protein JCG9;
GN Name=OR8D1; Synonyms=OR8D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-102.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8D1";
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DR EMBL; AF238489; AAL32998.1; -; mRNA.
DR EMBL; AB065828; BAC06047.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67578.1; -; Genomic_DNA.
DR EMBL; BC136950; AAI36951.1; -; mRNA.
DR EMBL; BC136954; AAI36955.1; -; mRNA.
DR EMBL; BK004501; DAA04899.1; -; Genomic_DNA.
DR CCDS; CCDS31706.1; -.
DR RefSeq; NP_001002917.1; NM_001002917.1.
DR AlphaFoldDB; Q8WZ84; -.
DR SMR; Q8WZ84; -.
DR STRING; 9606.ENSP00000350474; -.
DR GlyGen; Q8WZ84; 2 sites.
DR iPTMnet; Q8WZ84; -.
DR PhosphoSitePlus; Q8WZ84; -.
DR BioMuta; OR8D1; -.
DR DMDM; 20532189; -.
DR MassIVE; Q8WZ84; -.
DR PaxDb; Q8WZ84; -.
DR PeptideAtlas; Q8WZ84; -.
DR PRIDE; Q8WZ84; -.
DR Antibodypedia; 56808; 74 antibodies from 20 providers.
DR DNASU; 283159; -.
DR Ensembl; ENST00000357821.2; ENSP00000350474.2; ENSG00000196341.3.
DR Ensembl; ENST00000641015.1; ENSP00000493365.1; ENSG00000196341.3.
DR Ensembl; ENST00000641897.1; ENSP00000493091.1; ENSG00000196341.3.
DR GeneID; 283159; -.
DR KEGG; hsa:283159; -.
DR MANE-Select; ENST00000641015.1; ENSP00000493365.1; NM_001002917.2; NP_001002917.1.
DR UCSC; uc010sag.3; human.
DR CTD; 283159; -.
DR GeneCards; OR8D1; -.
DR HGNC; HGNC:8481; OR8D1.
DR HPA; ENSG00000196341; Not detected.
DR neXtProt; NX_Q8WZ84; -.
DR OpenTargets; ENSG00000196341; -.
DR PharmGKB; PA32760; -.
DR VEuPathDB; HostDB:ENSG00000196341; -.
DR eggNOG; ENOG502T9KP; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8WZ84; -.
DR OMA; KKNMILY; -.
DR OrthoDB; 1034130at2759; -.
DR PhylomeDB; Q8WZ84; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8WZ84; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283159; 139 hits in 667 CRISPR screens.
DR GeneWiki; OR8D1; -.
DR GenomeRNAi; 283159; -.
DR Pharos; Q8WZ84; Tdark.
DR PRO; PR:Q8WZ84; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8WZ84; protein.
DR Bgee; ENSG00000196341; Expressed in skin of hip and 5 other tissues.
DR ExpressionAtlas; Q8WZ84; baseline and differential.
DR Genevisible; Q8WZ84; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 8D1"
FT /id="PRO_0000150659"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 102
FT /note="F -> V (in dbSNP:rs2510433)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_053242"
FT VARIANT 127
FT /note="C -> W (in dbSNP:rs7107539)"
FT /id="VAR_053243"
FT VARIANT 194
FT /note="L -> P (in dbSNP:rs4936919)"
FT /id="VAR_024116"
SQ SEQUENCE 308 AA; 34445 MW; 5471E1ADA26F81FA CRC64;
MTMENYSMAA QFVLDGLTQQ AELQLPLFLL FLGIYVVTVV GNLGMILLIA VSPLLHTPMY
YFLSSLSFVD FCYSSVITPK MLVNFLGKKN TILYSECMVQ LFFFVVFVVA EGYLLTAMAY
DRYVAICSPL LYNAIMSSWV CSLLVLAAFF LGFLSALTHT SAMMKLSFCK SHIINHYFCD
VLPLLNLSCS NTHLNELLLF IIAGFNTLVP TLAVAVSYAF ILYSILHIRS SEGRSKAFGT
CSSHLMAVVI FFGSITFMYF KPPSSNSLDQ EKVSSVFYTT VIPMLNPLIY SLRNKDVKKA
LRKVLVGK
