OR8D2_HUMAN
ID OR8D2_HUMAN Reviewed; 311 AA.
AC Q9GZM6; B9EH49; Q6IFR0;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Olfactory receptor 8D2;
DE AltName: Full=Olfactory receptor OR11-303;
DE AltName: Full=Olfactory receptor-like protein JCG2;
GN Name=OR8D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8D2";
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DR EMBL; AF162668; AAG43386.1; -; mRNA.
DR EMBL; AF162669; AAG43387.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67579.1; -; Genomic_DNA.
DR EMBL; BC137043; AAI37044.1; -; mRNA.
DR EMBL; BC137045; AAI37046.1; -; mRNA.
DR EMBL; BK004202; DAA04600.1; -; Genomic_DNA.
DR RefSeq; NP_001002918.1; NM_001002918.1.
DR AlphaFoldDB; Q9GZM6; -.
DR SMR; Q9GZM6; -.
DR BioGRID; 129481; 1.
DR IntAct; Q9GZM6; 2.
DR STRING; 9606.ENSP00000350022; -.
DR GlyGen; Q9GZM6; 1 site.
DR iPTMnet; Q9GZM6; -.
DR PhosphoSitePlus; Q9GZM6; -.
DR BioMuta; OR8D2; -.
DR DMDM; 14423803; -.
DR MassIVE; Q9GZM6; -.
DR PaxDb; Q9GZM6; -.
DR PeptideAtlas; Q9GZM6; -.
DR PRIDE; Q9GZM6; -.
DR Antibodypedia; 78406; 18 antibodies from 11 providers.
DR DNASU; 283160; -.
DR Ensembl; ENST00000624618.2; ENSP00000485661.1; ENSG00000279116.3.
DR GeneID; 283160; -.
DR KEGG; hsa:283160; -.
DR MANE-Select; ENST00000624618.2; ENSP00000485661.1; NM_001002918.1; NP_001002918.1.
DR UCSC; uc010sah.2; human.
DR CTD; 283160; -.
DR GeneCards; OR8D2; -.
DR HGNC; HGNC:8482; OR8D2.
DR HPA; ENSG00000279116; Not detected.
DR neXtProt; NX_Q9GZM6; -.
DR PharmGKB; PA32761; -.
DR VEuPathDB; HostDB:ENSG00000279116; -.
DR eggNOG; ENOG502T37F; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9GZM6; -.
DR OMA; EGLTKCP; -.
DR OrthoDB; 957085at2759; -.
DR PhylomeDB; Q9GZM6; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q9GZM6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9GZM6; -.
DR BioGRID-ORCS; 283160; 10 hits in 662 CRISPR screens.
DR GeneWiki; OR8D2; -.
DR GenomeRNAi; 283160; -.
DR Pharos; Q9GZM6; Tdark.
DR PRO; PR:Q9GZM6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9GZM6; protein.
DR Bgee; ENSG00000279116; Expressed in material anatomical entity and 8 other tissues.
DR ExpressionAtlas; Q9GZM6; baseline and differential.
DR Genevisible; Q9GZM6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 8D2"
FT /id="PRO_0000150660"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 122
FT /note="R -> H (in dbSNP:rs2512219)"
FT /id="VAR_024117"
FT VARIANT 263
FT /note="P -> L (in dbSNP:rs2466620)"
FT /id="VAR_053244"
SQ SEQUENCE 311 AA; 34857 MW; ECE606FBBC962A82 CRC64;
MATSNHSSGA EFILAGLTQR PELQLPLFLL FLGIYVVTVV GNLGMIFLIA LSSQLYPPVY
YFLSHLSFID LCYSSVITPK MLVNFVPEEN IISFLECITQ LYFFLIFVIA EGYLLTAMEY
DRYVAICRPL LYNIVMSHRV CSIMMAVVYS LGFLWATVHT TRMSVLSFCR SHTVSHYFCD
ILPLLTLSCS STHINEILLF IIGGVNTLAT TLAVLISYAF IFSSILGIHS TEGQSKAFGT
CSSHLLAVGI FFGSITFMYF KPPSSTTMEK EKVSSVFYIT IIPMLNPLIY SLRNKDVKNA
LKKMTRGRQS S
