OR8D4_HUMAN
ID OR8D4_HUMAN Reviewed; 314 AA.
AC Q8NGM9; Q6IFE9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 8D4;
DE AltName: Full=Olfactory receptor OR11-275;
GN Name=OR8D4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8D4";
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DR EMBL; AB065761; BAC05981.1; -; Genomic_DNA.
DR EMBL; BC137180; AAI37181.1; -; mRNA.
DR EMBL; BC137206; AAI37207.1; -; mRNA.
DR EMBL; BK004313; DAA04711.1; -; Genomic_DNA.
DR CCDS; CCDS31698.1; -.
DR RefSeq; NP_001005197.1; NM_001005197.1.
DR AlphaFoldDB; Q8NGM9; -.
DR SMR; Q8NGM9; -.
DR BioGRID; 130777; 1.
DR STRING; 9606.ENSP00000325381; -.
DR GlyGen; Q8NGM9; 1 site.
DR iPTMnet; Q8NGM9; -.
DR PhosphoSitePlus; Q8NGM9; -.
DR BioMuta; OR8D4; -.
DR DMDM; 38372729; -.
DR MassIVE; Q8NGM9; -.
DR PaxDb; Q8NGM9; -.
DR PRIDE; Q8NGM9; -.
DR Antibodypedia; 56775; 74 antibodies from 19 providers.
DR DNASU; 338662; -.
DR Ensembl; ENST00000321355.3; ENSP00000325381.2; ENSG00000181518.4.
DR Ensembl; ENST00000641687.1; ENSP00000493391.1; ENSG00000181518.4.
DR GeneID; 338662; -.
DR KEGG; hsa:338662; -.
DR MANE-Select; ENST00000641687.1; ENSP00000493391.1; NM_001005197.2; NP_001005197.1.
DR UCSC; uc010saa.3; human.
DR CTD; 338662; -.
DR GeneCards; OR8D4; -.
DR HGNC; HGNC:14840; OR8D4.
DR HPA; ENSG00000181518; Not detected.
DR neXtProt; NX_Q8NGM9; -.
DR PharmGKB; PA32762; -.
DR VEuPathDB; HostDB:ENSG00000181518; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGM9; -.
DR OMA; CIFIISE; -.
DR OrthoDB; 936700at2759; -.
DR PhylomeDB; Q8NGM9; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGM9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 338662; 13 hits in 669 CRISPR screens.
DR GeneWiki; OR8D4; -.
DR GenomeRNAi; 338662; -.
DR Pharos; Q8NGM9; Tdark.
DR PRO; PR:Q8NGM9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGM9; protein.
DR Bgee; ENSG00000181518; Expressed in body of pancreas and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 8D4"
FT /id="PRO_0000150661"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 55
FT /note="L -> R (in dbSNP:rs17127947)"
FT /id="VAR_034257"
FT VARIANT 92
FT /note="I -> V (in dbSNP:rs17127950)"
FT /id="VAR_034258"
FT VARIANT 120
FT /note="C -> Y (in dbSNP:rs10750250)"
FT /id="VAR_053245"
FT VARIANT 133
FT /note="R -> K (in dbSNP:rs7926767)"
FT /id="VAR_024118"
FT VARIANT 200
FT /note="F -> L (in dbSNP:rs10790610)"
FT /id="VAR_024119"
FT VARIANT 205
FT /note="F -> S (in dbSNP:rs12270203)"
FT /id="VAR_034259"
FT VARIANT 283
FT /note="L -> P (in dbSNP:rs7942047)"
FT /id="VAR_024120"
FT VARIANT 298
FT /note="R -> K (in dbSNP:rs7927385)"
FT /id="VAR_024121"
SQ SEQUENCE 314 AA; 35019 MW; 7D9AB003A8D3B0DA CRC64;
MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR LNRQLHTPMY
YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ LFFFCVCVIS ECYMLAAMAC
DRYVAICSPL LYRVIMSPRV CSLLVAAVFS VGFTDAVIHG GCILRLSFCG SNIIKHYFCD
IVPLIKLSCS STYIDELLIF VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST
CSSHLTAVLM FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA
LMKLLRRKIS LSPG
