OR8G1_HUMAN
ID OR8G1_HUMAN Reviewed; 311 AA.
AC Q15617; Q8NG88;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 8G1;
DE AltName: Full=Olfactory receptor OR11-281;
DE AltName: Full=Olfactory receptor TPCR25;
GN Name=OR8G1; Synonyms=OR8G1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [6]
RP POLYMORPHISM.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon in the gene coding for this protein at
CC position Tyr-259 is responsible for functional diversity thus producing
CC thus a pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8G1";
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DR EMBL; AB065946; BAC06159.1; -; Genomic_DNA.
DR EMBL; X89672; CAA61819.1; -; mRNA.
DR EMBL; AF399507; AAK94992.1; -; Genomic_DNA.
DR EMBL; BK004423; DAA04821.1; -; Genomic_DNA.
DR CCDS; CCDS73407.1; -.
DR PIR; S58017; S58017.
DR RefSeq; NP_001002905.1; NM_001002905.1.
DR AlphaFoldDB; Q15617; -.
DR SMR; Q15617; -.
DR STRING; 9606.ENSP00000476313; -.
DR GlyGen; Q15617; 2 sites.
DR iPTMnet; Q15617; -.
DR PhosphoSitePlus; Q15617; -.
DR BioMuta; OR8G1; -.
DR DMDM; 82592515; -.
DR MassIVE; Q15617; -.
DR PeptideAtlas; Q15617; -.
DR PRIDE; Q15617; -.
DR ProteomicsDB; 60658; -.
DR Antibodypedia; 72302; 49 antibodies from 15 providers.
DR DNASU; 26494; -.
DR Ensembl; ENST00000641972.1; ENSP00000493289.1; ENSG00000197849.7.
DR GeneID; 26494; -.
DR KEGG; hsa:26494; -.
DR MANE-Select; ENST00000641972.1; ENSP00000493289.1; NM_001002905.2; NP_001002905.1.
DR UCSC; uc031yin.1; human.
DR CTD; 26494; -.
DR GeneCards; OR8G1; -.
DR HGNC; HGNC:8484; OR8G1.
DR HPA; ENSG00000197849; Not detected.
DR neXtProt; NX_Q15617; -.
DR PharmGKB; PA32764; -.
DR VEuPathDB; HostDB:ENSG00000197849; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q15617; -.
DR OMA; FNVINHY; -.
DR OrthoDB; 1075792at2759; -.
DR PhylomeDB; Q15617; -.
DR PathwayCommons; Q15617; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26494; 4 hits in 190 CRISPR screens.
DR GeneWiki; OR8G1; -.
DR GenomeRNAi; 26494; -.
DR Pharos; Q15617; Tdark.
DR PRO; PR:Q15617; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q15617; protein.
DR Bgee; ENSG00000197849; Expressed in secondary oocyte and 7 other tissues.
DR ExpressionAtlas; Q15617; baseline and differential.
DR Genevisible; Q15617; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 8G1"
FT /id="PRO_0000150662"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 247
FT /note="A -> V (in dbSNP:rs4482039)"
FT /id="VAR_034260"
SQ SEQUENCE 311 AA; 34904 MW; 0E28F95C37960C3E CRC64;
MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW LSSHLHTPMY
YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY
DRYMAICSPL LYSVIISNKA CFSLILGVYI IGLVCASVHT GCMFRVQFCK FDLINHYFCD
LLPLLKLSCS SIYVNKLLIL CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST
CSSHMLAVVI FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS
LKKMLQRRTL L
