OR8G5_HUMAN
ID OR8G5_HUMAN Reviewed; 346 AA.
AC Q8NG78; B2RND3; Q6IEU6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 8G5;
DE AltName: Full=Olfactory receptor 8G6;
DE AltName: Full=Olfactory receptor OR11-298;
GN Name=OR8G5; Synonyms=OR8G5P, OR8G6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06171.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8G5";
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DR EMBL; AB065958; BAC06171.1; ALT_INIT; Genomic_DNA.
DR EMBL; AP002965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136820; AAI36821.1; -; mRNA.
DR EMBL; BK004516; DAA04914.1; -; Genomic_DNA.
DR RefSeq; NP_001005198.1; NM_001005198.1.
DR RefSeq; XP_011540964.1; XM_011542662.2.
DR RefSeq; XP_011540965.1; XM_011542663.2.
DR RefSeq; XP_011540966.1; XM_011542664.2.
DR RefSeq; XP_011540967.1; XM_011542665.2.
DR RefSeq; XP_011540968.1; XM_011542666.2.
DR RefSeq; XP_011540969.1; XM_011542667.2.
DR AlphaFoldDB; Q8NG78; -.
DR SMR; Q8NG78; -.
DR BioGRID; 128586; 2.
DR STRING; 9606.ENSP00000477014; -.
DR GlyGen; Q8NG78; 2 sites.
DR iPTMnet; Q8NG78; -.
DR PhosphoSitePlus; Q8NG78; -.
DR BioMuta; OR8G5; -.
DR MassIVE; Q8NG78; -.
DR PeptideAtlas; Q8NG78; -.
DR PRIDE; Q8NG78; -.
DR DNASU; 219865; -.
DR GeneID; 219865; -.
DR KEGG; hsa:219865; -.
DR UCSC; uc031yio.1; human.
DR CTD; 219865; -.
DR GeneCards; OR8G5; -.
DR HGNC; HGNC:19622; OR8G5.
DR neXtProt; NX_Q8NG78; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG78; -.
DR OrthoDB; 1075792at2759; -.
DR PathwayCommons; Q8NG78; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219865; 5 hits in 635 CRISPR screens.
DR GeneWiki; OR8G5; -.
DR GenomeRNAi; 219865; -.
DR Pharos; Q8NG78; Tdark.
DR PRO; PR:Q8NG78; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NG78; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..346
FT /note="Olfactory receptor 8G5"
FT /id="PRO_0000150664"
FT TOPO_DOM 1..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..134
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..174
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..252
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 132..214
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 346 AA; 38798 MW; 4CE6344D67DB9C0D CRC64;
MIIYKQGITF LQKENNNTIH LNTMFFLSPA ETHQRMAAEN HSFVTKFILV GLTEKSELQL
PLFLVFLGIY VVTVLGNLGM ITLIGLSSHL HTPMYCFLSS LSFIDFCHST VITPKMLVNF
VTEKNIISYP ECMTQLYFFL VFAIAECHML AAMAYDGYVA ICSPLLYSII ISNKACFSLI
LVVYVIGLIC ASAHIGCMFR VQFCKFDVIN HYFCDLISIL KLSCSSTYIN ELLILIFSGI
NILVPSLTIL SSYIFIIASI LRIRYTEGRS KAFSTCSSHI SAVSVFFGSA AFMYLQPSSV
SSMDQGKVSS VFYTIVVPML NPLIYSLRNK DVHVALKKTL GKRTFL
