OR8H1_HUMAN
ID OR8H1_HUMAN Reviewed; 311 AA.
AC Q8NGG4; B2RNI7; Q6IFC5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 8H1;
DE AltName: Full=Olfactory receptor OR11-180;
GN Name=OR8H1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8H1";
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DR EMBL; AB065836; BAC06055.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73707.1; -; Genomic_DNA.
DR EMBL; BC136909; AAI36910.1; -; mRNA.
DR EMBL; BC136910; AAI36911.1; -; mRNA.
DR EMBL; BK004337; DAA04735.1; -; Genomic_DNA.
DR CCDS; CCDS31526.1; -.
DR RefSeq; NP_001005199.1; NM_001005199.1.
DR AlphaFoldDB; Q8NGG4; -.
DR SMR; Q8NGG4; -.
DR STRING; 9606.ENSP00000323595; -.
DR GlyGen; Q8NGG4; 1 site.
DR iPTMnet; Q8NGG4; -.
DR PhosphoSitePlus; Q8NGG4; -.
DR BioMuta; OR8H1; -.
DR DMDM; 38372687; -.
DR MassIVE; Q8NGG4; -.
DR PaxDb; Q8NGG4; -.
DR PeptideAtlas; Q8NGG4; -.
DR PRIDE; Q8NGG4; -.
DR Antibodypedia; 72065; 26 antibodies from 11 providers.
DR DNASU; 219469; -.
DR Ensembl; ENST00000313022.2; ENSP00000323595.2; ENSG00000181693.9.
DR Ensembl; ENST00000626711.1; ENSP00000486842.1; ENSG00000262611.4.
DR Ensembl; ENST00000641600.1; ENSP00000493316.1; ENSG00000181693.9.
DR GeneID; 219469; -.
DR KEGG; hsa:219469; -.
DR MANE-Select; ENST00000641600.1; ENSP00000493316.1; NM_001005199.2; NP_001005199.1.
DR UCSC; uc010rje.3; human.
DR CTD; 219469; -.
DR GeneCards; OR8H1; -.
DR HGNC; HGNC:14824; OR8H1.
DR HPA; ENSG00000181693; Not detected.
DR neXtProt; NX_Q8NGG4; -.
DR PharmGKB; PA32767; -.
DR VEuPathDB; HostDB:ENSG00000181693; -.
DR eggNOG; ENOG502SKRH; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR InParanoid; Q8NGG4; -.
DR OMA; MICILAG; -.
DR OrthoDB; 1063925at2759; -.
DR PhylomeDB; Q8NGG4; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGG4; -.
DR BioGRID-ORCS; 219469; 8 hits in 603 CRISPR screens.
DR GeneWiki; OR8H1; -.
DR GenomeRNAi; 219469; -.
DR Pharos; Q8NGG4; Tdark.
DR PRO; PR:Q8NGG4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG4; protein.
DR Bgee; ENSG00000181693; Expressed in arterial blood vessel and 2 other tissues.
DR ExpressionAtlas; Q8NGG4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 8H1"
FT /id="PRO_0000150665"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 2
FT /note="G -> S (in dbSNP:rs11600896)"
FT /id="VAR_053246"
FT VARIANT 22
FT /note="E -> V (in dbSNP:rs17540861)"
FT /id="VAR_034261"
SQ SEQUENCE 311 AA; 35228 MW; B2E5484AE80C2BB2 CRC64;
MGRRNNTNVP DFILTGLSDS EEVQMALFIL FLLIYLITML GNVGMILIIR LDLQLHTPMY
FFLTHLSFID LSYSTVITPK TLANLLTSNY ISFMGCFAQM FFFVFLGAAE CFLLSSMAYD
RYVAICSPLR YPVIMSKRLC CALVTGPYVI SFINSFVNVV WMSRLHFCDS NVVRHFFCDT
SPILALSCMD TYDIEIMIHI LAGSTLMVSL ITISASYVSI LSTILKINST SGKQKALSTC
ASHLLGVTIF YGTMIFTYLK PRKSYSLGRD QVASVFYTIV IPMLNPLIYS LRNKEVKNAL
IRVMQRRQDS R
