OR8H2_HUMAN
ID OR8H2_HUMAN Reviewed; 312 AA.
AC Q8N162; Q6IFC1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 8H2;
DE AltName: Full=Olfactory receptor OR11-171;
GN Name=OR8H2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8H2";
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DR EMBL; AB065657; BAC05883.1; -; Genomic_DNA.
DR EMBL; AB065845; BAC06063.1; -; Genomic_DNA.
DR EMBL; BK004341; DAA04739.1; -; Genomic_DNA.
DR CCDS; CCDS31518.1; -.
DR RefSeq; NP_001005200.1; NM_001005200.1.
DR AlphaFoldDB; Q8N162; -.
DR SMR; Q8N162; -.
DR BioGRID; 133421; 2.
DR STRING; 9606.ENSP00000323982; -.
DR GlyGen; Q8N162; 1 site.
DR iPTMnet; Q8N162; -.
DR PhosphoSitePlus; Q8N162; -.
DR BioMuta; OR8H2; -.
DR DMDM; 38372643; -.
DR MassIVE; Q8N162; -.
DR PaxDb; Q8N162; -.
DR PeptideAtlas; Q8N162; -.
DR PRIDE; Q8N162; -.
DR Antibodypedia; 58958; 92 antibodies from 21 providers.
DR DNASU; 390151; -.
DR Ensembl; ENST00000313503.2; ENSP00000323982.1; ENSG00000181767.3.
DR Ensembl; ENST00000641311.1; ENSP00000493031.1; ENSG00000181767.3.
DR GeneID; 390151; -.
DR KEGG; hsa:390151; -.
DR MANE-Select; ENST00000313503.2; ENSP00000323982.1; NM_001386064.1; NP_001372993.1.
DR UCSC; uc010riy.2; human.
DR CTD; 390151; -.
DR GeneCards; OR8H2; -.
DR HGNC; HGNC:15308; OR8H2.
DR HPA; ENSG00000181767; Not detected.
DR neXtProt; NX_Q8N162; -.
DR PharmGKB; PA32768; -.
DR VEuPathDB; HostDB:ENSG00000181767; -.
DR eggNOG; ENOG502SKRH; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR InParanoid; Q8N162; -.
DR OMA; SAVIRIM; -.
DR OrthoDB; 1063925at2759; -.
DR PhylomeDB; Q8N162; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8N162; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390151; 10 hits in 604 CRISPR screens.
DR GeneWiki; OR8H2; -.
DR GenomeRNAi; 390151; -.
DR Pharos; Q8N162; Tdark.
DR PRO; PR:Q8N162; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N162; protein.
DR ExpressionAtlas; Q8N162; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 8H2"
FT /id="PRO_0000150666"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 120
FT /note="H -> Y (in dbSNP:rs2512961)"
FT /id="VAR_034262"
FT VARIANT 169
FT /note="Y -> C (in dbSNP:rs2449148)"
FT /id="VAR_034263"
FT VARIANT 284
FT /note="V -> M (in dbSNP:rs1842696)"
FT /id="VAR_062060"
SQ SEQUENCE 312 AA; 35422 MW; 0D5112EF980EC13E CRC64;
MMGRRNNTNV ADFILMGLTL SEEIQMALFM LFLLIYLITM LGNVGMILII RLDLQLHTPM
YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ MFFFAFLGTA ECYLLSSMAH
DRYAAICSPL HYTVIMSKRL CLALITGPYV IGFIDSFVNV VSMSRLHFYD SNVIHHFFCD
TSPILALSCT DTYNTEILIF IIVGSTLMVS LFTISASYVF ILFTILKINS TSGKQKAFST
CVSHLLGVTI FYSTLIFTYL KPRKSYSLGR DQVASVFYTI VIPVLNPLIY SLRNKEVKNA
VIRVMQRRQD SR
