OR8H3_HUMAN
ID OR8H3_HUMAN Reviewed; 312 AA.
AC Q8N146; Q6IFB7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 8H3;
DE AltName: Full=Olfactory receptor OR11-172;
GN Name=OR8H3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8H3";
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DR EMBL; AB065658; BAC05884.1; -; Genomic_DNA.
DR EMBL; AB065840; BAC06059.1; -; Genomic_DNA.
DR EMBL; BK004345; DAA04743.1; -; Genomic_DNA.
DR CCDS; CCDS31519.1; -.
DR RefSeq; NP_001005201.1; NM_001005201.1.
DR AlphaFoldDB; Q8N146; -.
DR SMR; Q8N146; -.
DR STRING; 9606.ENSP00000323928; -.
DR GlyGen; Q8N146; 1 site.
DR BioMuta; OR8H3; -.
DR DMDM; 38372641; -.
DR MassIVE; Q8N146; -.
DR PaxDb; Q8N146; -.
DR PeptideAtlas; Q8N146; -.
DR PRIDE; Q8N146; -.
DR Antibodypedia; 58959; 43 antibodies from 14 providers.
DR DNASU; 390152; -.
DR Ensembl; ENST00000313472.3; ENSP00000323928.3; ENSG00000181761.5.
DR GeneID; 390152; -.
DR KEGG; hsa:390152; -.
DR MANE-Select; ENST00000313472.3; ENSP00000323928.3; NM_001005201.1; NP_001005201.1.
DR UCSC; uc001nii.1; human.
DR CTD; 390152; -.
DR DisGeNET; 390152; -.
DR GeneCards; OR8H3; -.
DR HGNC; HGNC:15309; OR8H3.
DR HPA; ENSG00000181761; Not detected.
DR neXtProt; NX_Q8N146; -.
DR OpenTargets; ENSG00000181761; -.
DR PharmGKB; PA32769; -.
DR VEuPathDB; HostDB:ENSG00000181761; -.
DR eggNOG; ENOG502SKRH; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8N146; -.
DR OMA; THVVEII; -.
DR OrthoDB; 1063925at2759; -.
DR PhylomeDB; Q8N146; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8N146; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390152; 14 hits in 591 CRISPR screens.
DR GeneWiki; OR8H3; -.
DR GenomeRNAi; 390152; -.
DR Pharos; Q8N146; Tdark.
DR PRO; PR:Q8N146; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N146; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 8H3"
FT /id="PRO_0000150667"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 47
FT /note="L -> I (in dbSNP:rs7107077)"
FT /id="VAR_060012"
FT VARIANT 137
FT /note="P -> S (in dbSNP:rs1842691)"
FT /id="VAR_034264"
FT VARIANT 201
FT /note="I -> V (in dbSNP:rs17531522)"
FT /id="VAR_024122"
FT VARIANT 295
FT /note="R -> K (in dbSNP:rs11606538)"
FT /id="VAR_034265"
SQ SEQUENCE 312 AA; 35219 MW; 328AC0E2BC8DCDD1 CRC64;
MMGRRNDTNV ADFILTGLSD SEEVQMALFM LFLLIYLITM LGNVGMLLII RLDLQLHTPM
YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ MFCFVFLGTA ECYLLSSMAY
DRYAAICSPL HYTVIMPKRL CLALITGPYV IGFMDSFVNV VSMSRLHFCD SNIIHHFFCD
TSPILALSCT DTDNTEMLIF IIAGSTLMVS LITISASYVS ILSTILKINS TSGKQKAFST
CVSHLLGVTI FYGTMIFTYL KPRKSYSLGR DQVAPVFYTI VIPMLNPLIY SLRNREVKNA
LIRVMQRRQD SR
