OR8I2_HUMAN
ID OR8I2_HUMAN Reviewed; 310 AA.
AC Q8N0Y5; B2RNN4; Q6IFC0; Q96RC5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 8I2;
DE AltName: Full=Olfactory receptor OR11-170;
GN Name=OR8I2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8I2";
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DR EMBL; AB065656; BAC05882.1; -; Genomic_DNA.
DR EMBL; AB065844; BAC06062.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73697.1; -; Genomic_DNA.
DR EMBL; BC137007; AAI37008.1; -; mRNA.
DR EMBL; BC137008; AAI37009.1; -; mRNA.
DR EMBL; AF399513; AAK94998.1; -; Genomic_DNA.
DR EMBL; BK004342; DAA04740.1; -; Genomic_DNA.
DR CCDS; CCDS31517.1; -.
DR RefSeq; NP_001003750.1; NM_001003750.1.
DR AlphaFoldDB; Q8N0Y5; -.
DR SMR; Q8N0Y5; -.
DR BioGRID; 125691; 1.
DR STRING; 9606.ENSP00000303864; -.
DR GlyGen; Q8N0Y5; 1 site.
DR BioMuta; OR8I2; -.
DR DMDM; 38372639; -.
DR MassIVE; Q8N0Y5; -.
DR PaxDb; Q8N0Y5; -.
DR PeptideAtlas; Q8N0Y5; -.
DR PRIDE; Q8N0Y5; -.
DR Antibodypedia; 58957; 55 antibodies from 18 providers.
DR DNASU; 120586; -.
DR Ensembl; ENST00000302124.8; ENSP00000303864.2; ENSG00000172154.11.
DR GeneID; 120586; -.
DR KEGG; hsa:120586; -.
DR MANE-Select; ENST00000302124.8; ENSP00000303864.2; NM_001003750.1; NP_001003750.1.
DR UCSC; uc010rix.2; human.
DR CTD; 120586; -.
DR DisGeNET; 120586; -.
DR GeneCards; OR8I2; -.
DR HGNC; HGNC:15310; OR8I2.
DR HPA; ENSG00000172154; Not detected.
DR neXtProt; NX_Q8N0Y5; -.
DR OpenTargets; ENSG00000172154; -.
DR PharmGKB; PA32771; -.
DR VEuPathDB; HostDB:ENSG00000172154; -.
DR eggNOG; ENOG502SKRH; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8N0Y5; -.
DR OMA; MAGNNFT; -.
DR OrthoDB; 1012182at2759; -.
DR PhylomeDB; Q8N0Y5; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8N0Y5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8N0Y5; -.
DR BioGRID-ORCS; 120586; 21 hits in 620 CRISPR screens.
DR GeneWiki; OR8I2; -.
DR GenomeRNAi; 120586; -.
DR Pharos; Q8N0Y5; Tdark.
DR PRO; PR:Q8N0Y5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N0Y5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 8I2"
FT /id="PRO_0000150668"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 124
FT /note="I -> V (in dbSNP:rs17603011)"
FT /id="VAR_034266"
FT VARIANT 139
FT /note="K -> N (in dbSNP:rs17150021)"
FT /id="VAR_034267"
SQ SEQUENCE 310 AA; 34661 MW; BF92BD882CFD7263 CRC64;
MAGNNFTEVT VFILSGFANH PELQVSLFLM FLFIYLFTVL GNLGLITLIR MDSQLHTPMY
FFLSNLAFID IFYSSTVTPK ALVNFQSNRR SISFVGCFVQ MYFFVGLVCC ECFLLGSMAY
NRYIAICNPL LYSVVMSQKV SNWLGVMPYV IGFTSSLISV WVISSLAFCD SSINHFFCDT
TALLALSCVD TFGTEMVSFV LAGFTLLSSL LIITVTYIII ISAILRIQSA AGRQKAFSTC
ASHLMAVTIF YGSLIFTYLQ PDNTSSLTQA QVASVFYTIV IPMLNPLIYS LRNKDVKNAL
LRVIHRKLFP
