OR8J1_HUMAN
ID OR8J1_HUMAN Reviewed; 316 AA.
AC Q8NGP2; B2RNQ6; B9EH63; Q6IFC2; Q96RC3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 8J1;
DE AltName: Full=Olfactory receptor OR11-183;
GN Name=OR8J1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-120.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-120.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284, AND VARIANT CYS-120.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION, AND VARIANT CYS-120.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8J1";
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DR EMBL; AB065748; BAC05968.1; -; Genomic_DNA.
DR EMBL; AF399515; AAK95000.1; -; Genomic_DNA.
DR EMBL; AP002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137066; AAI37067.1; -; mRNA.
DR EMBL; BC137067; AAI37068.1; -; mRNA.
DR EMBL; BK004340; DAA04738.1; -; Genomic_DNA.
DR CCDS; CCDS31529.1; -.
DR RefSeq; NP_001005205.2; NM_001005205.2.
DR AlphaFoldDB; Q8NGP2; -.
DR SMR; Q8NGP2; -.
DR STRING; 9606.ENSP00000304060; -.
DR GlyGen; Q8NGP2; 1 site.
DR iPTMnet; Q8NGP2; -.
DR PhosphoSitePlus; Q8NGP2; -.
DR BioMuta; OR8J1; -.
DR DMDM; 296439255; -.
DR MassIVE; Q8NGP2; -.
DR PaxDb; Q8NGP2; -.
DR PeptideAtlas; Q8NGP2; -.
DR PRIDE; Q8NGP2; -.
DR Antibodypedia; 58978; 50 antibodies from 13 providers.
DR DNASU; 219477; -.
DR Ensembl; ENST00000303039.3; ENSP00000304060.3; ENSG00000172487.4.
DR Ensembl; ENST00000533152.3; ENSP00000477259.3; ENSG00000172487.4.
DR Ensembl; ENST00000574644.1; ENSP00000460206.1; ENSG00000262796.1.
DR GeneID; 219477; -.
DR KEGG; hsa:219477; -.
DR MANE-Select; ENST00000533152.3; ENSP00000477259.3; NM_001005205.3; NP_001005205.2.
DR UCSC; uc010rjh.2; human.
DR CTD; 219477; -.
DR DisGeNET; 219477; -.
DR GeneCards; OR8J1; -.
DR HGNC; HGNC:14855; OR8J1.
DR HPA; ENSG00000172487; Not detected.
DR neXtProt; NX_Q8NGP2; -.
DR PharmGKB; PA32772; -.
DR VEuPathDB; HostDB:ENSG00000172487; -.
DR eggNOG; ENOG502SMQ4; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGP2; -.
DR OMA; CASHMMS; -.
DR OrthoDB; 980876at2759; -.
DR PhylomeDB; Q8NGP2; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGP2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219477; 6 hits in 588 CRISPR screens.
DR GeneWiki; OR8J1; -.
DR GenomeRNAi; 219477; -.
DR Pharos; Q8NGP2; Tdark.
DR PRO; PR:Q8NGP2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP2; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 8J1"
FT /id="PRO_0000150669"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 36
FT /note="G -> V (in dbSNP:rs7927015)"
FT /id="VAR_034268"
FT VARIANT 114
FT /note="M -> L (in dbSNP:rs7942730)"
FT /id="VAR_034269"
FT VARIANT 120
FT /note="Y -> C (in dbSNP:rs10896290)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:14983052, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.1"
FT /id="VAR_060013"
SQ SEQUENCE 316 AA; 35415 MW; 8EDA4AFC2D918868 CRC64;
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYGLTMA GNLGIITLTS VDSRLQTPMY
FFLQHLALIN LGNSTVIAPK MLINFLVKKK TTSFYECATQ LGGFLFFIVS EVIMLALMAY
DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS SYVFSVSYCS SNIINHFYCD
NVPLLALSCS DTYLPETVVF ISAATNVVGS LIIVLVSYFN IVLSILKICS SEGRKKAFST
CASHMMAVTI FYGTLLFMYV QPRSNHSLDT DDKMASVFYT LVIPMLNPLI YSLRNKDVKT
ALQRFMTNLC YSFKTM
