OR8J3_HUMAN
ID OR8J3_HUMAN Reviewed; 315 AA.
AC Q8NGG0; Q6IFB6; Q96RC2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 8J3;
DE AltName: Full=Olfactory receptor OR11-173;
GN Name=OR8J3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANT PHE-208.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8J3";
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DR EMBL; AB065841; BAC06060.1; -; Genomic_DNA.
DR EMBL; AF399516; AAK95001.1; -; Genomic_DNA.
DR EMBL; BK004346; DAA04744.1; -; Genomic_DNA.
DR CCDS; CCDS31520.1; -.
DR RefSeq; NP_001004064.1; NM_001004064.1.
DR AlphaFoldDB; Q8NGG0; -.
DR SMR; Q8NGG0; -.
DR STRING; 9606.ENSP00000301529; -.
DR GlyGen; Q8NGG0; 2 sites.
DR iPTMnet; Q8NGG0; -.
DR PhosphoSitePlus; Q8NGG0; -.
DR BioMuta; OR8J3; -.
DR DMDM; 38372684; -.
DR MassIVE; Q8NGG0; -.
DR PaxDb; Q8NGG0; -.
DR PeptideAtlas; Q8NGG0; -.
DR PRIDE; Q8NGG0; -.
DR ProteomicsDB; 73502; -.
DR Antibodypedia; 58960; 95 antibodies from 19 providers.
DR DNASU; 81168; -.
DR Ensembl; ENST00000641913.1; ENSP00000493417.1; ENSG00000167822.3.
DR Ensembl; ENST00000642058.1; ENSP00000493166.1; ENSG00000167822.3.
DR GeneID; 81168; -.
DR KEGG; hsa:81168; -.
DR MANE-Select; ENST00000642058.1; ENSP00000493166.1; NM_001004064.2; NP_001004064.1.
DR UCSC; uc010riz.2; human.
DR CTD; 81168; -.
DR GeneCards; OR8J3; -.
DR HGNC; HGNC:15312; OR8J3.
DR HPA; ENSG00000167822; Not detected.
DR neXtProt; NX_Q8NGG0; -.
DR PharmGKB; PA32774; -.
DR VEuPathDB; HostDB:ENSG00000167822; -.
DR eggNOG; ENOG502SMQ4; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGG0; -.
DR OMA; IFSMSYC; -.
DR OrthoDB; 980876at2759; -.
DR PhylomeDB; Q8NGG0; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81168; 12 hits in 672 CRISPR screens.
DR GeneWiki; OR8J3; -.
DR GenomeRNAi; 81168; -.
DR Pharos; Q8NGG0; Tdark.
DR PRO; PR:Q8NGG0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG0; protein.
DR ExpressionAtlas; Q8NGG0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 8J3"
FT /id="PRO_0000150670"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 57
FT /note="N -> T (in dbSNP:rs1947924)"
FT /id="VAR_048052"
FT VARIANT 87
FT /note="V -> I (in dbSNP:rs7937461)"
FT /id="VAR_048053"
FT VARIANT 208
FT /note="V -> F (in dbSNP:rs1384094)"
FT /evidence="ECO:0000269|PubMed:12213199"
FT /id="VAR_048054"
FT VARIANT 271
FT /note="D -> E (in dbSNP:rs17150102)"
FT /id="VAR_048055"
SQ SEQUENCE 315 AA; 35481 MW; EBC2E1724FCC4D2E CRC64;
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS VDSRLQNPMY
FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ LGGFLFFIVS EVMMLAVMAY
DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS PCIFSVSYCS SNIINHFYCD
IAPLLALSCS DTYIPETIVF ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST
CASHMIAVTV FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA
LKKFMENPCY SFKSM
