OR8K1_HUMAN
ID OR8K1_HUMAN Reviewed; 319 AA.
AC Q8NGG5; B9EJB1; Q6IFC3; Q96RC1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 8K1;
DE AltName: Full=Olfactory receptor OR11-182;
GN Name=OR8K1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-84.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-289.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8K1";
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DR EMBL; AB065835; BAC06054.1; -; Genomic_DNA.
DR EMBL; BC146844; AAI46845.1; -; mRNA.
DR EMBL; AF399517; AAK95002.1; -; Genomic_DNA.
DR EMBL; BK004339; DAA04737.1; -; Genomic_DNA.
DR CCDS; CCDS31528.1; -.
DR RefSeq; NP_001002907.1; NM_001002907.1.
DR AlphaFoldDB; Q8NGG5; -.
DR SMR; Q8NGG5; -.
DR STRING; 9606.ENSP00000279783; -.
DR GlyGen; Q8NGG5; 1 site.
DR BioMuta; OR8K1; -.
DR DMDM; 38372688; -.
DR MassIVE; Q8NGG5; -.
DR PaxDb; Q8NGG5; -.
DR PeptideAtlas; Q8NGG5; -.
DR PRIDE; Q8NGG5; -.
DR Antibodypedia; 58977; 92 antibodies from 20 providers.
DR DNASU; 390157; -.
DR Ensembl; ENST00000279783.5; ENSP00000279783.2; ENSG00000150261.5.
DR Ensembl; ENST00000574800.2; ENSP00000461384.1; ENSG00000263328.2.
DR GeneID; 390157; -.
DR KEGG; hsa:390157; -.
DR MANE-Select; ENST00000279783.5; ENSP00000279783.2; NM_001002907.1; NP_001002907.1.
DR UCSC; uc010rjg.2; human.
DR CTD; 390157; -.
DR GeneCards; OR8K1; -.
DR HGNC; HGNC:14831; OR8K1.
DR HPA; ENSG00000150261; Not detected.
DR neXtProt; NX_Q8NGG5; -.
DR PharmGKB; PA32775; -.
DR VEuPathDB; HostDB:ENSG00000150261; -.
DR eggNOG; ENOG502RU1H; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG5; -.
DR OMA; PLMSILC; -.
DR OrthoDB; 993549at2759; -.
DR PhylomeDB; Q8NGG5; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390157; 29 hits in 665 CRISPR screens.
DR GeneWiki; OR8K1; -.
DR GenomeRNAi; 390157; -.
DR Pharos; Q8NGG5; Tdark.
DR PRO; PR:Q8NGG5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGG5; protein.
DR Bgee; ENSG00000150261; Expressed in uterine cervix and 1 other tissue.
DR ExpressionAtlas; Q8NGG5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 8K1"
FT /id="PRO_0000150671"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 21
FT /note="M -> V (in dbSNP:rs10896271)"
FT /id="VAR_034270"
FT VARIANT 27
FT /note="P -> T (in dbSNP:rs10896272)"
FT /id="VAR_034271"
FT VARIANT 84
FT /note="A -> T (in dbSNP:rs17614327)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034272"
SQ SEQUENCE 319 AA; 36581 MW; 9CB4F7F94917E9D5 CRC64;
MNHVVKHNHT AVTKVTEFIL MGITDNPGLQ APLFGLFLII YLVTVIGNLG MVILTYLDSK
LHTPMYFFLR HLSITDLGYS TVIAPKMLVN FIVHKNTISY NWYATQLAFF EIFIISELFI
LSAMAYDRYV AICKPLLYVI IMAEKVLWVL VIVPYLYSTF VSLFLTIKLF KLSFCGSNII
SYFYCDCIPL MSILCSDTNE LELIILIFSG CNLLFSLSIV LISYMFILVA ILRMNSRKGR
YKAFSTCSSH LTVVIMFYGT LLFIYLQPKS SHTLAIDKMA SVFYTLLIPM LNPLIYSLRN
KEVKDALKRT LTNRFKIPI
