OR8K3_HUMAN
ID OR8K3_HUMAN Reviewed; 312 AA.
AC Q8NH51; Q6IFC4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 8K3;
DE AltName: Full=Olfactory receptor OR11-181;
GN Name=OR8K3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8K3";
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DR EMBL; AB065541; BAC05786.1; -; Genomic_DNA.
DR EMBL; BK004338; DAA04736.1; -; Genomic_DNA.
DR RefSeq; NP_001005202.1; NM_001005202.1.
DR AlphaFoldDB; Q8NH51; -.
DR SMR; Q8NH51; -.
DR STRING; 9606.ENSP00000323555; -.
DR GlyGen; Q8NH51; 1 site.
DR iPTMnet; Q8NH51; -.
DR PhosphoSitePlus; Q8NH51; -.
DR BioMuta; OR8K3; -.
DR DMDM; 38372810; -.
DR MassIVE; Q8NH51; -.
DR PaxDb; Q8NH51; -.
DR PeptideAtlas; Q8NH51; -.
DR PRIDE; Q8NH51; -.
DR ProteomicsDB; 73660; -.
DR Antibodypedia; 78716; 73 antibodies from 18 providers.
DR DNASU; 219473; -.
DR Ensembl; ENST00000573400.1; ENSP00000460880.1; ENSG00000262755.1.
DR Ensembl; ENST00000641662.1; ENSP00000493271.1; ENSG00000280314.4.
DR Ensembl; ENST00000641689.1; ENSP00000493440.1; ENSG00000280314.4.
DR GeneID; 219473; -.
DR KEGG; hsa:219473; -.
DR MANE-Select; ENST00000641662.1; ENSP00000493271.1; NM_001005202.2; NP_001005202.1.
DR UCSC; uc010rjf.2; human.
DR CTD; 219473; -.
DR GeneCards; OR8K3; -.
DR HGNC; HGNC:15313; OR8K3.
DR HPA; ENSG00000280314; Not detected.
DR neXtProt; NX_Q8NH51; -.
DR PharmGKB; PA32777; -.
DR VEuPathDB; HostDB:ENSG00000280314; -.
DR eggNOG; ENOG502SHX8; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH51; -.
DR OMA; RMWKKIC; -.
DR OrthoDB; 1023470at2759; -.
DR PhylomeDB; Q8NH51; -.
DR TreeFam; TF352749; -.
DR PathwayCommons; Q8NH51; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219473; 9 hits in 661 CRISPR screens.
DR GeneWiki; OR8K3; -.
DR GenomeRNAi; 219473; -.
DR Pharos; Q8NH51; Tdark.
DR PRO; PR:Q8NH51; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH51; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 8K3"
FT /id="PRO_0000150672"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 122
FT /note="L -> R (in dbSNP:rs960193)"
FT /id="VAR_024123"
FT VARIANT 173
FT /note="V -> I (in dbSNP:rs12291617)"
FT /id="VAR_034273"
FT VARIANT 275
FT /note="I -> M (in dbSNP:rs17150317)"
FT /id="VAR_034274"
SQ SEQUENCE 312 AA; 35463 MW; ED061A5992DB4212 CRC64;
MEQHNLTTVN EFILTGITDI AELQAPLFAL FLMIYVISVM GNLGMIVLTK LDSRLQTPMY
FFLRHLAFMD LGYSTTVGPK MLVNFVVDKN IISYYFCATQ LAFFLVFIGS ELFILSAMSY
DLYVAICNPL LYTVIMSRRV CQVLVAIPYL YCTFISLLVT IKIFTLSFCG YNVISHFYCD
SLPLLPLLCS NTHEIELIIL IFAAIDLISS LLIVLLSYLL ILVAILRMNS AGRQKAFSTC
GAHLTVVIVF YGTLLFMYVQ PKSSHSFDTD KVASIFYTLV IPMLNPLIYS LRNKDVKYAL
RRTWNNLCNI FV
