OR8K5_HUMAN
ID OR8K5_HUMAN Reviewed; 307 AA.
AC Q8NH50; Q6IFB5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 8K5;
DE AltName: Full=Olfactory receptor OR11-174;
GN Name=OR8K5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8K5";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065542; BAC05787.1; -; Genomic_DNA.
DR EMBL; BK004347; DAA04745.1; -; Genomic_DNA.
DR CCDS; CCDS31521.1; -.
DR RefSeq; NP_001004058.2; NM_001004058.2.
DR AlphaFoldDB; Q8NH50; -.
DR SMR; Q8NH50; -.
DR STRING; 9606.ENSP00000323853; -.
DR GlyGen; Q8NH50; 2 sites.
DR iPTMnet; Q8NH50; -.
DR PhosphoSitePlus; Q8NH50; -.
DR BioMuta; OR8K5; -.
DR DMDM; 38372809; -.
DR MassIVE; Q8NH50; -.
DR PaxDb; Q8NH50; -.
DR PRIDE; Q8NH50; -.
DR Antibodypedia; 72061; 17 antibodies from 10 providers.
DR DNASU; 219453; -.
DR Ensembl; ENST00000313447.1; ENSP00000323853.1; ENSG00000181752.3.
DR GeneID; 219453; -.
DR KEGG; hsa:219453; -.
DR MANE-Select; ENST00000313447.1; ENSP00000323853.1; NM_001004058.2; NP_001004058.2.
DR UCSC; uc010rja.2; human.
DR CTD; 219453; -.
DR GeneCards; OR8K5; -.
DR HGNC; HGNC:15315; OR8K5.
DR HPA; ENSG00000181752; Not detected.
DR neXtProt; NX_Q8NH50; -.
DR PharmGKB; PA32779; -.
DR VEuPathDB; HostDB:ENSG00000181752; -.
DR eggNOG; ENOG502T922; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH50; -.
DR OMA; GNSTTIC; -.
DR OrthoDB; 1091850at2759; -.
DR PhylomeDB; Q8NH50; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NH50; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219453; 13 hits in 669 CRISPR screens.
DR GeneWiki; OR8K5; -.
DR GenomeRNAi; 219453; -.
DR Pharos; Q8NH50; Tdark.
DR PRO; PR:Q8NH50; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH50; protein.
DR Bgee; ENSG00000181752; Expressed in ganglionic eminence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 8K5"
FT /id="PRO_0000150673"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 68
FT /note="F -> S (in dbSNP:rs2512938)"
FT /id="VAR_048056"
SQ SEQUENCE 307 AA; 35190 MW; AC636BBB0D94ED18 CRC64;
MGQHNLTVLT EFILMELTRR PELQIPLFGV FLVIYLITVV GNLTMIILTK LDSHLHTPMY
FSIRHLAFVD LGNSTVICPK VLANFVVDRN TISYYACAAQ LAFFLMFIIS EFFILSAMAY
DRYVAICNPL LYYVIMSQRL CHVLVGIQYL YSTFQALMFT IKIFTLTFCG SNVISHFYCD
DVPLLPMLCS NAQEIELLSI LFSVFNLISS FLIVLVSYML ILLAICQMHS AEGRKKAFST
CGSHLTVVVV FYGSLLFMYM QPNSTHFFDT DKMASVFYTL VIPMLNPLIY SLRNEEVKNA
FYKLFEN
