OR8U1_HUMAN
ID OR8U1_HUMAN Reviewed; 309 AA.
AC Q8NH10;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 8U1;
GN Name=OR8U1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8U1";
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DR EMBL; AB065603; BAC05831.1; -; Genomic_DNA.
DR CCDS; CCDS41647.1; -.
DR RefSeq; NP_001005204.1; NM_001005204.1.
DR AlphaFoldDB; Q8NH10; -.
DR SMR; Q8NH10; -.
DR BioGRID; 128529; 1.
DR STRING; 9606.ENSP00000304188; -.
DR GlyGen; Q8NH10; 1 site.
DR BioMuta; OR8U1; -.
DR DMDM; 74762588; -.
DR PaxDb; Q8NH10; -.
DR PeptideAtlas; Q8NH10; -.
DR PRIDE; Q8NH10; -.
DR Antibodypedia; 58979; 34 antibodies from 10 providers.
DR DNASU; 219417; -.
DR Ensembl; ENST00000302270.1; ENSP00000304188.1; ENSG00000172199.1.
DR GeneID; 219417; -.
DR KEGG; hsa:219417; -.
DR MANE-Select; ENST00000302270.1; ENSP00000304188.1; NM_001005204.1; NP_001005204.1.
DR UCSC; uc031xpd.1; human.
DR CTD; 219417; -.
DR GeneCards; OR8U1; -.
DR HGNC; HGNC:19611; OR8U1.
DR HPA; ENSG00000172199; Not detected.
DR neXtProt; NX_Q8NH10; -.
DR OpenTargets; ENSG00000172199; -.
DR PharmGKB; PA134970669; -.
DR VEuPathDB; HostDB:ENSG00000172199; -.
DR eggNOG; ENOG502RF3K; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH10; -.
DR OMA; NQAFMFM; -.
DR OrthoDB; 1053355at2759; -.
DR PhylomeDB; Q8NH10; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NH10; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219417; 10 hits in 640 CRISPR screens.
DR ChiTaRS; OR8U1; human.
DR GenomeRNAi; 219417; -.
DR Pharos; Q8NH10; Tdark.
DR PRO; PR:Q8NH10; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH10; protein.
DR Bgee; ENSG00000172199; Expressed in aorta and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 8U1"
FT /id="PRO_0000150675"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="H -> R (in dbSNP:rs11228166)"
FT /id="VAR_053247"
FT VARIANT 109
FT /note="I -> V (in dbSNP:rs12788990)"
FT /id="VAR_053248"
FT VARIANT 112
FT /note="S -> C (in dbSNP:rs10791961)"
FT /id="VAR_053249"
FT VARIANT 137
FT /note="T -> S (in dbSNP:rs10791962)"
FT /id="VAR_060014"
FT VARIANT 165
FT /note="R -> C (in dbSNP:rs17150411)"
FT /id="VAR_053250"
FT VARIANT 206
FT /note="M -> I (in dbSNP:rs10896310)"
FT /id="VAR_060015"
FT VARIANT 206
FT /note="M -> T (in dbSNP:rs10896309)"
FT /id="VAR_060016"
FT VARIANT 288
FT /note="L -> V (in dbSNP:rs1573509)"
FT /id="VAR_053251"
FT VARIANT 293
FT /note="Q -> R (in dbSNP:rs12272403)"
FT /id="VAR_053252"
SQ SEQUENCE 309 AA; 35088 MW; 5EDA2E45FB2A1548 CRC64;
MAHINCTQAT EFILVGLTDH QELKMPLFVL FLSIYLFTVV GNLGLILLIR ADTSLNTPMY
FFLSNLAFVD FCYSSVITPK MLGNFLYKQN VISFDACATQ LGCFLTFMIS ESLLLASMAY
DRYVAICNPL LYMVVMTPGI CIQLVAVPYS YSFLMALFHT ILTFRLSYCH SNIVNHFYCD
DMPLLRLTCS DTRFKQLWIF ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST
CGSHMLAVTI FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA
LKKIIINKN
