OR8U8_HUMAN
ID OR8U8_HUMAN Reviewed; 319 AA.
AC P0C7N1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Olfactory receptor 8U8;
GN Name=OR8U8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8U8";
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DR EMBL; CH471076; EAW73711.1; -; Genomic_DNA.
DR RefSeq; NP_001013374.2; NM_001013356.2.
DR AlphaFoldDB; P0C7N1; -.
DR SMR; P0C7N1; -.
DR IntAct; P0C7N1; 1.
DR GlyGen; P0C7N1; 1 site.
DR BioMuta; OR8U8; -.
DR DMDM; 190359931; -.
DR MassIVE; P0C7N1; -.
DR PeptideAtlas; P0C7N1; -.
DR PRIDE; P0C7N1; -.
DR DNASU; 504189; -.
DR GeneID; 504189; -.
DR KEGG; hsa:504189; -.
DR CTD; 504189; -.
DR GeneCards; OR8U8; -.
DR HGNC; HGNC:27538; OR8U8.
DR neXtProt; NX_P0C7N1; -.
DR PharmGKB; PA142671222; -.
DR InParanoid; P0C7N1; -.
DR OrthoDB; 1053355at2759; -.
DR PhylomeDB; P0C7N1; -.
DR PathwayCommons; P0C7N1; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; P0C7N1; Tdark.
DR PRO; PR:P0C7N1; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C7N1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 8U8"
FT /id="PRO_0000339640"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 319 AA; 36334 MW; 61A2F3D81A4239AB CRC64;
MAHINCTQAT EFILVGLTDH QELKMPLFVL FLSIYLFTVV GNLGLILLIR ADTSLNTPMY
FFLSNLAFVD FCYSSVITPK MLGNFLYKQN VISFDACATQ LGCFLTFMVS ESLLLASMAY
DRYVAICNPL LYMVVMTPGI CIQLVAVPYS YSFLMALFHT ILTFRLSYCH SNIVNHFYCD
DMPLLRLTCS DTRFKQLWIL ACAGITFICS VLIVFVSYMF IIFAILRMSS AEGRRKAFST
CSSHMLAVTI FYGTLIFMYL QPSSSHSLDA DKMASVFYTV IIPMLNPLIY SLRNKDVKDA
LKKVIINRNH AFIFLKLRK
