OR8U9_HUMAN
ID OR8U9_HUMAN Reviewed; 309 AA.
AC P0C7N5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Olfactory receptor 8U9;
GN Name=OR8U9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8U9";
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DR EMBL; CH471076; EAW73667.1; -; Genomic_DNA.
DR RefSeq; NP_001013375.1; NM_001013357.1.
DR AlphaFoldDB; P0C7N5; -.
DR SMR; P0C7N5; -.
DR GlyGen; P0C7N5; 1 site.
DR BioMuta; HGNC:29166; -.
DR DMDM; 190359932; -.
DR PeptideAtlas; P0C7N5; -.
DR PRIDE; P0C7N5; -.
DR DNASU; 504190; -.
DR Ensembl; ENST00000626074.1; ENSP00000487204.1; ENSG00000281038.1.
DR GeneID; 504190; -.
DR KEGG; hsa:504190; -.
DR UCSC; uc031yko.1; human.
DR CTD; 504190; -.
DR GeneCards; OR8U9; -.
DR HGNC; HGNC:29166; OR8U9.
DR neXtProt; NX_P0C7N5; -.
DR PharmGKB; PA142671223; -.
DR InParanoid; P0C7N5; -.
DR OrthoDB; 1053355at2759; -.
DR PathwayCommons; P0C7N5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 504190; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 504190; -.
DR Pharos; P0C7N5; Tdark.
DR PRO; PR:P0C7N5; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C7N5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 8U9"
FT /id="PRO_0000341277"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 35054 MW; A3B36EADA680A15F CRC64;
MTQINCTQVT EFILVGLTDR QELKMPLFVL FLSIYLFTVV GNLGLILLIR TDEKLNTPMY
FFLSNLAFVD FCYSSVITPK MLGNFLYKQN SISFNACAAQ LGCFLAFMTA ECLLLASMAY
DRYVAICNPL MYMVVMSPGI CIQLVAAPHS YSILVALFHT ILTFRLSYCH SNIVNHFYCD
DMPLLRLTCS DTRFKQLWIF ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST
CGSHMLAVTI FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA
LKKIIINKN
