OR9A2_HUMAN
ID OR9A2_HUMAN Reviewed; 310 AA.
AC Q8NGT5; B9EH51; Q6IF71; Q8NGD9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 9A2;
DE AltName: Full=Olfactory receptor OR7-2;
GN Name=OR9A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9A2";
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DR EMBL; AB065696; BAC05919.1; -; Genomic_DNA.
DR EMBL; AB065874; BAC06092.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51890.1; -; Genomic_DNA.
DR EMBL; BC137048; AAI37049.1; -; mRNA.
DR EMBL; BC137049; AAI37050.1; -; mRNA.
DR EMBL; BK004391; DAA04789.1; -; Genomic_DNA.
DR CCDS; CCDS34767.1; -.
DR RefSeq; NP_001001658.1; NM_001001658.1.
DR AlphaFoldDB; Q8NGT5; -.
DR SMR; Q8NGT5; -.
DR STRING; 9606.ENSP00000316518; -.
DR GlyGen; Q8NGT5; 1 site.
DR PhosphoSitePlus; Q8NGT5; -.
DR BioMuta; OR9A2; -.
DR DMDM; 38372770; -.
DR PaxDb; Q8NGT5; -.
DR PRIDE; Q8NGT5; -.
DR Antibodypedia; 64633; 62 antibodies from 17 providers.
DR DNASU; 135924; -.
DR Ensembl; ENST00000350513.3; ENSP00000316518.3; ENSG00000179468.6.
DR Ensembl; ENST00000619330.2; ENSP00000479412.1; ENSG00000273914.2.
DR GeneID; 135924; -.
DR KEGG; hsa:135924; -.
DR MANE-Select; ENST00000350513.3; ENSP00000316518.3; NM_001001658.1; NP_001001658.1.
DR UCSC; uc003wcc.2; human.
DR CTD; 135924; -.
DR GeneCards; OR9A2; -.
DR HGNC; HGNC:15093; OR9A2.
DR HPA; ENSG00000179468; Tissue enriched (brain).
DR neXtProt; NX_Q8NGT5; -.
DR OpenTargets; ENSG00000179468; -.
DR PharmGKB; PA32785; -.
DR VEuPathDB; HostDB:ENSG00000179468; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000163070; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NGT5; -.
DR OMA; HHILFAM; -.
DR OrthoDB; 1093378at2759; -.
DR PhylomeDB; Q8NGT5; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NGT5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 135924; 9 hits in 672 CRISPR screens.
DR GeneWiki; OR9A2; -.
DR GenomeRNAi; 135924; -.
DR Pharos; Q8NGT5; Tdark.
DR PRO; PR:Q8NGT5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NGT5; protein.
DR Bgee; ENSG00000179468; Expressed in corpus callosum and 15 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 9A2"
FT /id="PRO_0000150676"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 53
FT /note="R -> H (in dbSNP:rs9885986)"
FT /id="VAR_053253"
SQ SEQUENCE 310 AA; 35330 MW; 276463E878614FE0 CRC64;
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV DKRLQSPMYF
FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN FSCGTMEFAL LGVMAVDRYV
AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL SEIWPIYATF QFTFRKSNSL DHFYCDRGQL
LKLSCDNTLL TEFILFLMAV FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH
FTCVVIGYGS CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
MKRCCQLLKD
