OR9A4_HUMAN
ID OR9A4_HUMAN Reviewed; 314 AA.
AC Q8NGU2; B9EGV6; Q6IFI4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 9A4;
DE AltName: Full=Olfactory receptor OR7-1;
GN Name=OR9A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9A4";
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DR EMBL; AB065689; BAC05912.1; -; Genomic_DNA.
DR EMBL; CH236950; EAL24013.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83990.1; -; Genomic_DNA.
DR EMBL; BC136819; AAI36820.1; -; mRNA.
DR EMBL; BC136821; AAI36822.1; -; mRNA.
DR EMBL; BK004278; DAA04676.1; -; Genomic_DNA.
DR CCDS; CCDS43661.1; -.
DR RefSeq; NP_001001656.1; NM_001001656.1.
DR AlphaFoldDB; Q8NGU2; -.
DR SMR; Q8NGU2; -.
DR BioGRID; 126222; 1.
DR STRING; 9606.ENSP00000448789; -.
DR GlyGen; Q8NGU2; 2 sites.
DR iPTMnet; Q8NGU2; -.
DR PhosphoSitePlus; Q8NGU2; -.
DR BioMuta; OR9A4; -.
DR DMDM; 38372772; -.
DR jPOST; Q8NGU2; -.
DR PaxDb; Q8NGU2; -.
DR PRIDE; Q8NGU2; -.
DR Antibodypedia; 57873; 6 antibodies from 6 providers.
DR DNASU; 130075; -.
DR Ensembl; ENST00000548136.1; ENSP00000448789.1; ENSG00000258083.2.
DR Ensembl; ENST00000641559.1; ENSP00000493151.1; ENSG00000258083.2.
DR GeneID; 130075; -.
DR KEGG; hsa:130075; -.
DR MANE-Select; ENST00000641559.1; ENSP00000493151.1; NM_001001656.3; NP_001001656.1.
DR UCSC; uc003vwu.2; human.
DR CTD; 130075; -.
DR GeneCards; OR9A4; -.
DR HGNC; HGNC:15095; OR9A4.
DR HPA; ENSG00000258083; Not detected.
DR neXtProt; NX_Q8NGU2; -.
DR OpenTargets; ENSG00000258083; -.
DR PharmGKB; PA32787; -.
DR VEuPathDB; HostDB:ENSG00000258083; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000163413; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NGU2; -.
DR OMA; SYCKSNV; -.
DR OrthoDB; 1093378at2759; -.
DR PhylomeDB; Q8NGU2; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NGU2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 130075; 8 hits in 662 CRISPR screens.
DR GeneWiki; OR9A4; -.
DR GenomeRNAi; 130075; -.
DR Pharos; Q8NGU2; Tdark.
DR PRO; PR:Q8NGU2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NGU2; protein.
DR Bgee; ENSG00000258083; Expressed in bone marrow and 10 other tissues.
DR ExpressionAtlas; Q8NGU2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 9A4"
FT /id="PRO_0000150677"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 35758 MW; 4F961C5C93750D1A CRC64;
MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV DKRLQSPMYF
FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ LFLYLAVGTT EFALLGAMAV
DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD
RGQLLKLSCN NTLFTEFILF LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST
CASHFTCVVI GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA
LRDGVKRCCQ LFRN
