OR9G1_HUMAN
ID OR9G1_HUMAN Reviewed; 305 AA.
AC Q8NH87; Q6IEU9; Q8NGQ0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 9G1;
DE AltName: Full=Olfactory receptor 9G5;
DE AltName: Full=Olfactory receptor OR11-114;
GN Name=OR9G1; Synonyms=OR9G5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9G1";
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DR EMBL; AB065500; BAC05750.1; -; Genomic_DNA.
DR EMBL; AB065739; BAC05960.1; -; Genomic_DNA.
DR EMBL; BK004513; DAA04911.1; -; Genomic_DNA.
DR CCDS; CCDS31536.1; -.
DR RefSeq; NP_001005213.1; NM_001005213.1.
DR AlphaFoldDB; Q8NH87; -.
DR SMR; Q8NH87; -.
DR BioGRID; 133432; 1.
DR STRING; 9606.ENSP00000309012; -.
DR GlyGen; Q8NH87; 1 site.
DR iPTMnet; Q8NH87; -.
DR PhosphoSitePlus; Q8NH87; -.
DR BioMuta; OR9G1; -.
DR DMDM; 38372827; -.
DR PaxDb; Q8NH87; -.
DR PeptideAtlas; Q8NH87; -.
DR PRIDE; Q8NH87; -.
DR Antibodypedia; 62751; 59 antibodies from 17 providers.
DR DNASU; 390174; -.
DR Ensembl; ENST00000642097.1; ENSP00000493255.1; ENSG00000174914.3.
DR GeneID; 390174; -.
DR KEGG; hsa:390174; -.
DR MANE-Select; ENST00000642097.1; ENSP00000493255.1; NM_001005213.2; NP_001005213.1.
DR UCSC; uc010rjn.2; human.
DR CTD; 390174; -.
DR DisGeNET; 390174; -.
DR GeneCards; OR9G1; -.
DR HGNC; HGNC:15319; OR9G1.
DR HPA; ENSG00000174914; Not detected.
DR neXtProt; NX_Q8NH87; -.
DR OpenTargets; ENSG00000174914; -.
DR PharmGKB; PA32788; -.
DR VEuPathDB; HostDB:ENSG00000174914; -.
DR eggNOG; ENOG502T862; Eukaryota.
DR GeneTree; ENSGT00940000154333; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH87; -.
DR OMA; FNFCREN; -.
DR OrthoDB; 927196at2759; -.
DR PhylomeDB; Q8NH87; -.
DR TreeFam; TF352735; -.
DR PathwayCommons; Q8NH87; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390174; 10 hits in 652 CRISPR screens.
DR GeneWiki; OR9G1; -.
DR GenomeRNAi; 390174; -.
DR Pharos; Q8NH87; Tdark.
DR PRO; PR:Q8NH87; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH87; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 9G1"
FT /id="PRO_0000150678"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 53
FT /note="C -> R (in dbSNP:rs532637)"
FT /id="VAR_032777"
FT VARIANT 53
FT /note="C -> Y (in dbSNP:rs532635)"
FT /id="VAR_060017"
FT VARIANT 61
FT /note="F -> V (in dbSNP:rs3975155)"
FT /id="VAR_032778"
FT VARIANT 62
FT /note="T -> I (in dbSNP:rs2865520)"
FT /id="VAR_060018"
FT VARIANT 83
FT /note="T -> I (in dbSNP:rs602224)"
FT /id="VAR_032779"
FT VARIANT 98
FT /note="C -> G (in dbSNP:rs11228732)"
FT /id="VAR_060019"
FT VARIANT 112
FT /note="Y -> C (in dbSNP:rs4990194)"
FT /id="VAR_032780"
FT VARIANT 117
FT /note="V -> M (in dbSNP:rs591369)"
FT /id="VAR_032781"
FT VARIANT 169
FT /note="R -> C (in dbSNP:rs11228733)"
FT /id="VAR_053254"
FT VARIANT 185
FT /note="E -> K (in dbSNP:rs11228735)"
FT /id="VAR_053255"
FT VARIANT 231
FT /note="K -> Q (in dbSNP:rs12420076)"
FT /id="VAR_053256"
FT VARIANT 233
FT /note="Y -> C (in dbSNP:rs10896517)"
FT /id="VAR_060020"
FT VARIANT 233
FT /note="Y -> H (in dbSNP:rs10896516)"
FT /id="VAR_060021"
FT VARIANT 259
FT /note="A -> S (in dbSNP:rs7121276)"
FT /id="VAR_034276"
FT CONFLICT 53
FT /note="C -> H (in Ref. 1; DAA04911/BAC05960)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="T -> V (in Ref. 1; DAA04911/BAC05960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34071 MW; B6452BB0DAAF5523 CRC64;
MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN DSCLHTPMYF
FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF FFSAGLAYSE CYLLAAVAYD
RYVAISKPLL YAQAMSIKLC ALLVAVSYCG GFINSSIITK KTFSFNFCRE NIIDDFFCDL
LPLVELACGE KGGYKIMMYF LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC
SSHLTSVTLY YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL
KKLLP
