OR9G4_HUMAN
ID OR9G4_HUMAN Reviewed; 327 AA.
AC Q8NGQ1; Q6IF62; Q96RA9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 9G4;
DE AltName: Full=Olfactory receptor OR11-216;
GN Name=OR9G4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9G4";
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DR EMBL; AB065738; BAC05959.1; ALT_INIT; Genomic_DNA.
DR EMBL; AP001803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399530; AAK95015.1; -; Genomic_DNA.
DR EMBL; BK004400; DAA04798.1; -; Genomic_DNA.
DR RefSeq; NP_001005284.1; NM_001005284.1.
DR AlphaFoldDB; Q8NGQ1; -.
DR SMR; Q8NGQ1; -.
DR STRING; 9606.ENSP00000307515; -.
DR GlyGen; Q8NGQ1; 1 site.
DR BioMuta; OR9G4; -.
DR DMDM; 212276456; -.
DR EPD; Q8NGQ1; -.
DR MassIVE; Q8NGQ1; -.
DR PaxDb; Q8NGQ1; -.
DR PeptideAtlas; Q8NGQ1; -.
DR PRIDE; Q8NGQ1; -.
DR DNASU; 283189; -.
DR Ensembl; ENST00000575017.3; ENSP00000459325.1; ENSG00000262647.3.
DR GeneID; 283189; -.
DR KEGG; hsa:283189; -.
DR UCSC; uc010rjo.3; human.
DR CTD; 283189; -.
DR GeneCards; OR9G4; -.
DR HGNC; HGNC:15322; OR9G4.
DR neXtProt; NX_Q8NGQ1; -.
DR PharmGKB; PA32791; -.
DR eggNOG; ENOG502SIHB; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGQ1; -.
DR OrthoDB; 1179321at2759; -.
DR PhylomeDB; Q8NGQ1; -.
DR TreeFam; TF352735; -.
DR PathwayCommons; Q8NGQ1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283189; 4 hits in 666 CRISPR screens.
DR GeneWiki; OR9G4; -.
DR GenomeRNAi; 283189; -.
DR Pharos; Q8NGQ1; Tdark.
DR PRO; PR:Q8NGQ1; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NGQ1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Olfactory receptor 9G4"
FT /id="PRO_0000150679"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 43
FT /note="F -> S (in dbSNP:rs11228763)"
FT /id="VAR_053257"
FT VARIANT 206
FT /note="N -> D (in dbSNP:rs577576)"
FT /id="VAR_053258"
FT VARIANT 222
FT /note="V -> A (in dbSNP:rs513873)"
FT /id="VAR_053259"
SQ SEQUENCE 327 AA; 36344 MW; 4607F3C763DD97D9 CRC64;
MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY LITLSGNMTL
VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC VSEDKRISLA GCGAQLFFSC
VVAYTECYLL AAMAYDRHAA ICNPLLYSGT MSTALCTGLV AGSYIGGFLN AIAHTANTFR
LHFCGKNIID HFFCDAPPLV KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI
LRIHSASGRH KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
NPLIYSLRNK DIKEAFRKAT QTIQPQT
