OR9I1_HUMAN
ID OR9I1_HUMAN Reviewed; 314 AA.
AC Q8NGQ6; Q6IFH0; Q96RA8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 9I1;
DE AltName: Full=Olfactory receptor OR11-228;
GN Name=OR9I1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9I1";
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DR EMBL; AB065733; BAC05954.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73796.1; -; Genomic_DNA.
DR EMBL; AF399531; AAK95016.1; -; Genomic_DNA.
DR EMBL; BK004292; DAA04690.1; -; Genomic_DNA.
DR CCDS; CCDS31542.1; -.
DR RefSeq; NP_001005211.1; NM_001005211.1.
DR AlphaFoldDB; Q8NGQ6; -.
DR SMR; Q8NGQ6; -.
DR BioGRID; 128599; 1.
DR STRING; 9606.ENSP00000302606; -.
DR GlyGen; Q8NGQ6; 1 site.
DR PhosphoSitePlus; Q8NGQ6; -.
DR BioMuta; OR9I1; -.
DR DMDM; 38372750; -.
DR jPOST; Q8NGQ6; -.
DR MassIVE; Q8NGQ6; -.
DR PaxDb; Q8NGQ6; -.
DR PeptideAtlas; Q8NGQ6; -.
DR PRIDE; Q8NGQ6; -.
DR Antibodypedia; 70677; 22 antibodies from 14 providers.
DR DNASU; 219954; -.
DR Ensembl; ENST00000641439.1; ENSP00000493370.1; ENSG00000172377.3.
DR Ensembl; ENST00000641478.1; ENSP00000493104.1; ENSG00000172377.3.
DR GeneID; 219954; -.
DR KEGG; hsa:219954; -.
DR MANE-Select; ENST00000641439.1; ENSP00000493370.1; NM_001005211.2; NP_001005211.1.
DR UCSC; uc001nml.1; human.
DR CTD; 219954; -.
DR GeneCards; OR9I1; -.
DR HGNC; HGNC:14718; OR9I1.
DR HPA; ENSG00000172377; Not detected.
DR neXtProt; NX_Q8NGQ6; -.
DR PharmGKB; PA32794; -.
DR VEuPathDB; HostDB:ENSG00000172377; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGQ6; -.
DR OMA; TLSFCDH; -.
DR OrthoDB; 866304at2759; -.
DR PhylomeDB; Q8NGQ6; -.
DR TreeFam; TF337111; -.
DR PathwayCommons; Q8NGQ6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219954; 17 hits in 675 CRISPR screens.
DR GeneWiki; OR9I1; -.
DR GenomeRNAi; 219954; -.
DR Pharos; Q8NGQ6; Tdark.
DR PRO; PR:Q8NGQ6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGQ6; protein.
DR ExpressionAtlas; Q8NGQ6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 9I1"
FT /id="PRO_0000150681"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 34908 MW; BCB7E6BC6ADA706A CRC64;
MAKNNLTRVT EFILMGFMDH PKLEIPLFLV FLSFYLVTLL GNVGMIMLIQ VDVKLYTPMY
FFLSHLSLLD ACYTSVITPQ ILATLATGKT VISYGHCAAQ FFLFTICAGT ECFLLAVMAY
DRYAAIRNPL LYTVAMNPRL CWSLVVGAYV CGVSGAILRT TCTFTLSFCK DNQINFFFCD
LPPLLKLACS DTANIEIVII FFGNFVILAN ASVILISYLL IIKTILKVKS SGGRAKTFST
CASHITAVAL FFGALIFMYL QSGSGKSLEE DKVVSVFYTV VIPMLNPLIY SLRNKDVKDA
FRKVARRLQV SLSM
