OR9K2_HUMAN
ID OR9K2_HUMAN Reviewed; 335 AA.
AC Q8NGE7; B9EH19; Q6IFD6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 9K2;
DE AltName: Full=Olfactory receptor OR12-2;
GN Name=OR9K2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06080.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9K2";
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DR EMBL; AB065862; BAC06080.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC136988; AAI36989.1; -; mRNA.
DR EMBL; BK004326; DAA04724.1; -; Genomic_DNA.
DR RefSeq; NP_001005243.1; NM_001005243.1.
DR AlphaFoldDB; Q8NGE7; -.
DR SMR; Q8NGE7; -.
DR STRING; 9606.ENSP00000307598; -.
DR GlyGen; Q8NGE7; 2 sites.
DR iPTMnet; Q8NGE7; -.
DR PhosphoSitePlus; Q8NGE7; -.
DR BioMuta; OR9K2; -.
DR DMDM; 218511732; -.
DR MassIVE; Q8NGE7; -.
DR PaxDb; Q8NGE7; -.
DR PeptideAtlas; Q8NGE7; -.
DR PRIDE; Q8NGE7; -.
DR Antibodypedia; 65934; 68 antibodies from 21 providers.
DR DNASU; 441639; -.
DR GeneID; 441639; -.
DR KEGG; hsa:441639; -.
DR UCSC; uc010spe.3; human.
DR CTD; 441639; -.
DR GeneCards; OR9K2; -.
DR HGNC; HGNC:15339; OR9K2.
DR HPA; ENSG00000170605; Not detected.
DR neXtProt; NX_Q8NGE7; -.
DR PharmGKB; PA32799; -.
DR VEuPathDB; HostDB:ENSG00000170605; -.
DR eggNOG; ENOG502SJ6B; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGE7; -.
DR OrthoDB; 976281at2759; -.
DR PhylomeDB; Q8NGE7; -.
DR TreeFam; TF352758; -.
DR PathwayCommons; Q8NGE7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 441639; 14 hits in 668 CRISPR screens.
DR GeneWiki; OR9K2; -.
DR GenomeRNAi; 441639; -.
DR Pharos; Q8NGE7; Tdark.
DR PRO; PR:Q8NGE7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NGE7; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="Olfactory receptor 9K2"
FT /id="PRO_0000150682"
FT TOPO_DOM 1..50
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 122..214
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 45
FT /note="R -> C (in dbSNP:rs12303066)"
FT /id="VAR_048057"
FT VARIANT 103
FT /note="E -> A (in dbSNP:rs7305779)"
FT /id="VAR_048058"
FT VARIANT 207
FT /note="R -> H (in dbSNP:rs7306491)"
FT /id="VAR_048059"
SQ SEQUENCE 335 AA; 37746 MW; 90454BC59D32F5F3 CRC64;
MLGSKPRVHL YILPCASQQV STMGDRGTSN HSEMTDFILA GFRVRPELHI LLFLLFLFVY
AMILLGNVGM MTIIMTDPRL NTPMYFFLGN LSFIDLFYSS VIEPKAMINF WSENKSISFA
GCVAQLFLFA LLIVTEGFLL AAMAYDRFIA ICNPLLYSVQ MSTRLCTQLV AGSYFCGCIS
SVIQTSMTFT LSFCASRAVD HFYCDSRPLQ RLSCSDLFIH RMISFSLSCI IILPTIIVII
VSYMYIVSTV LKIHSTEGHK KAFSTCSSHL GVVSVLYGAV FFMYLTPDRF PELSKVASLC
YSLVTPMLNP LIYSLRNKDV QEALKKFLEK KNIIL
