OR9Q1_HUMAN
ID OR9Q1_HUMAN Reviewed; 310 AA.
AC Q8NGQ5; Q2TAN3; Q96RA7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 9Q1;
GN Name=OR9Q1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9Q1";
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DR EMBL; AB065734; BAC05955.1; -; Genomic_DNA.
DR EMBL; AF399532; AAK95017.1; -; Genomic_DNA.
DR EMBL; BC110819; AAI10820.1; -; mRNA.
DR CCDS; CCDS31543.1; -.
DR RefSeq; NP_001005212.1; NM_001005212.3.
DR AlphaFoldDB; Q8NGQ5; -.
DR SMR; Q8NGQ5; -.
DR STRING; 9606.ENSP00000334934; -.
DR GlyGen; Q8NGQ5; 1 site.
DR iPTMnet; Q8NGQ5; -.
DR PhosphoSitePlus; Q8NGQ5; -.
DR BioMuta; OR9Q1; -.
DR DMDM; 38372749; -.
DR MassIVE; Q8NGQ5; -.
DR PaxDb; Q8NGQ5; -.
DR PeptideAtlas; Q8NGQ5; -.
DR PRIDE; Q8NGQ5; -.
DR Antibodypedia; 52716; 108 antibodies from 20 providers.
DR DNASU; 219956; -.
DR Ensembl; ENST00000335397.3; ENSP00000334934.3; ENSG00000186509.4.
DR Ensembl; ENST00000612174.1; ENSP00000479549.1; ENSG00000186509.4.
DR GeneID; 219956; -.
DR KEGG; hsa:219956; -.
DR MANE-Select; ENST00000335397.3; ENSP00000334934.3; NM_001005212.4; NP_001005212.1.
DR UCSC; uc001nmj.4; human.
DR CTD; 219956; -.
DR DisGeNET; 219956; -.
DR GeneCards; OR9Q1; -.
DR HGNC; HGNC:14724; OR9Q1.
DR HPA; ENSG00000186509; Not detected.
DR neXtProt; NX_Q8NGQ5; -.
DR OpenTargets; ENSG00000186509; -.
DR PharmGKB; PA32805; -.
DR VEuPathDB; HostDB:ENSG00000186509; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGQ5; -.
DR OMA; LIAFTDC; -.
DR OrthoDB; 1093391at2759; -.
DR PhylomeDB; Q8NGQ5; -.
DR TreeFam; TF337111; -.
DR PathwayCommons; Q8NGQ5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219956; 5 hits in 672 CRISPR screens.
DR ChiTaRS; OR9Q1; human.
DR GeneWiki; OR9Q1; -.
DR GenomeRNAi; 219956; -.
DR Pharos; Q8NGQ5; Tdark.
DR PRO; PR:Q8NGQ5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGQ5; protein.
DR Bgee; ENSG00000186509; Expressed in omental fat pad and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 9Q1"
FT /id="PRO_0000150683"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 159
FT /note="R -> L (in dbSNP:rs12420738)"
FT /id="VAR_053260"
SQ SEQUENCE 310 AA; 34757 MW; 6C27C347AE8FD741 CRC64;
MAEMNLTLVT EFLLIAFTEY PEWALPLFLL FLFMYLITVL GNLEMIILIL MDHQLHAPMY
FLLSHLAFMD VCYSSITVPQ MLAVLLEHGA ALSYTRCAAQ FFLFTFFGSI DCYLLALMAY
DRYLAVCQPL LYVTILTQQA RLSLVAGAYV AGLISALVRT VSAFTLSFCG TSEIDFIFCD
LPPLLKLTCG ESYTQEVLII MFAIFVIPAS MVVILVSYLF IIVAIMGIPA GSQAKTFSTC
TSHLTAVSLF FGTLIFMYLR GNSDQSSEKN RVVSVLYTEV IPMLNPLIYS LRNKEVKEAL
RKILNRAKLS
