OR9Q2_HUMAN
ID OR9Q2_HUMAN Reviewed; 314 AA.
AC Q8NGE9; B9EIK5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 9Q2;
GN Name=OR9Q2; Synonyms=OR9Q2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9Q2";
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DR EMBL; AB065859; BAC06077.1; -; Genomic_DNA.
DR EMBL; BC140718; AAI40719.1; -; mRNA.
DR CCDS; CCDS31544.1; -.
DR RefSeq; NP_001005283.1; NM_001005283.2.
DR AlphaFoldDB; Q8NGE9; -.
DR SMR; Q8NGE9; -.
DR BioGRID; 128601; 1.
DR IntAct; Q8NGE9; 1.
DR STRING; 9606.ENSP00000308714; -.
DR GlyGen; Q8NGE9; 1 site.
DR BioMuta; OR9Q2; -.
DR DMDM; 74762579; -.
DR MassIVE; Q8NGE9; -.
DR PaxDb; Q8NGE9; -.
DR PeptideAtlas; Q8NGE9; -.
DR PRIDE; Q8NGE9; -.
DR Antibodypedia; 58755; 57 antibodies from 18 providers.
DR DNASU; 219957; -.
DR Ensembl; ENST00000641291.1; ENSP00000492924.1; ENSG00000186513.4.
DR GeneID; 219957; -.
DR KEGG; hsa:219957; -.
DR MANE-Select; ENST00000641291.1; ENSP00000492924.1; NM_001005283.3; NP_001005283.1.
DR UCSC; uc010rka.2; human.
DR CTD; 219957; -.
DR GeneCards; OR9Q2; -.
DR HGNC; HGNC:15328; OR9Q2.
DR HPA; ENSG00000186513; Not detected.
DR neXtProt; NX_Q8NGE9; -.
DR PharmGKB; PA32806; -.
DR VEuPathDB; HostDB:ENSG00000186513; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGE9; -.
DR OMA; VFVMPVC; -.
DR OrthoDB; 1093391at2759; -.
DR PhylomeDB; Q8NGE9; -.
DR TreeFam; TF337111; -.
DR PathwayCommons; Q8NGE9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGE9; -.
DR BioGRID-ORCS; 219957; 13 hits in 669 CRISPR screens.
DR GenomeRNAi; 219957; -.
DR Pharos; Q8NGE9; Tdark.
DR PRO; PR:Q8NGE9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGE9; protein.
DR ExpressionAtlas; Q8NGE9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 9Q2"
FT /id="PRO_0000150684"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 179
FT /note="C -> R (in dbSNP:rs34337292)"
FT /id="VAR_062061"
FT CONFLICT 303
FT /note="K -> E (in Ref. 2; AAI40719)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35363 MW; EFD847443D8FDFD4 CRC64;
MAERNYTVVT EFFLTAFTEH LQWRVPLFLI FLSFYLATML GNTGMILLIR GDRRLHTPMY
FFLSHLSLVD ICYSSAIIPQ MLAVLWEHGT TISQARCAAQ FFLFTFFASI DCYLLAIMAY
DRYTAVCQPL LYVTIITEKA RWGLVTGAYV AGFFSAFVRT VTAFTLSFCG NNEINFIFCD
LPPLLKLSCG DSYTQEVVII VFALFVMPAC ILVILVSYLF IIVAILQIHS AGGRAKTFST
CASHLTAVAL FFGTLIFMYL RDNTGQSSEG DRVVSVLYTV VTPMLNPLIY SLRNKEVKEA
TRKALSKSKP ARRP
