ORA4_DANRE
ID ORA4_DANRE Reviewed; 344 AA.
AC A0A0R4IP11; A8E0X0; F6P1D8;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 1.
DT 03-AUG-2022, entry version 33.
DE RecName: Full=Olfactory receptor class A-like protein 4 {ECO:0000305};
GN Name=ora4 {ECO:0000312|ZFIN:ZDB-GENE-100721-6};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:CAO85676.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-171, AND TISSUE SPECIFICITY.
RC STRAIN=AB/Tu {ECO:0000312|EMBL:CAO85676.1};
RC TISSUE=Olfactory rosette {ECO:0000312|EMBL:CAO85676.1};
RX PubMed=17717047; DOI=10.1101/gr.6553207;
RA Saraiva L.R., Korsching S.I.;
RT "A novel olfactory receptor gene family in teleost fish.";
RL Genome Res. 17:1448-1457(2007).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=22038944; DOI=10.1093/chemse/bjr095;
RA Oka Y., Saraiva L.R., Korsching S.I.;
RT "Crypt neurons express a single V1R-related ora gene.";
RL Chem. Senses 37:219-227(2012).
CC -!- FUNCTION: Probable olfactory receptor. {ECO:0000305|PubMed:22038944}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the olfactory rosette
CC (PubMed:17717047). Specifically localizes to crypt neurons in the
CC olfactory neuroepithelium (PubMed:22038944). Colocalizes with the
CC inhibitory G-protein gnaia in crypt neurons (PubMed:22038944). Not
CC detected in other tissues tested (PubMed:17717047).
CC {ECO:0000269|PubMed:17717047, ECO:0000269|PubMed:22038944}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; CABZ01072989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU914780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AM778166; CAO85676.1; -; mRNA.
DR RefSeq; XP_005168339.1; XM_005168282.3.
DR AlphaFoldDB; A0A0R4IP11; -.
DR SMR; A0A0R4IP11; -.
DR STRING; 7955.ENSDARP00000097647; -.
DR PaxDb; A0A0R4IP11; -.
DR Ensembl; ENSDART00000160884; ENSDARP00000135814; ENSDARG00000078223.
DR GeneID; 100004842; -.
DR KEGG; dre:100004842; -.
DR CTD; 100004842; -.
DR ZFIN; ZDB-GENE-100721-6; ora4.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00650000093633; -.
DR HOGENOM; CLU_1639375_0_0_1; -.
DR OMA; LLGCIWE; -.
DR OrthoDB; 795846at2759; -.
DR PRO; PR:A0A0R4IP11; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000078223; Expressed in crypt olfactory receptor neuron and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Olfactory receptor class A-like protein 4"
FT /id="PRO_0000444570"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..47
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..84
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..186
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..279
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 324..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 83..169
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 344 AA; 37804 MW; B4765D142B5AF29F CRC64;
MSEVLTVDAV LFGLLVFSGI IGNIMVIYVV FDCAKLCASR HLPPSDTILV HLCLANLLTS
VFRTVPIFVS DLGLQVWLTA GWCRVFMLLW VWWRAVGCWV TLALSAFHCA TLRRQHVSMG
PLGHSRERRR VWVVLAVVWA ANLLFSLPAL VYTTQVRGNA TVELMVISCT TRPLLGCVWE
FPTFQQGYAF ASSSLALNEV LPLVLMVGTN LATLQALGKH IRTVRAGGST GAELDRHVSS
ERKAGHVIMA LVALFVGCWV LQVAAVTYYN HNRGAHAEGL LTVAHFSASL FVGFSPLVVA
LGHGKLRRRI SGILQSCMHR LKQTQDKPAE ITEKDGRTTQ SAMK
