ID   ORAI2_CHICK             Reviewed;         257 AA.
AC   Q5ZLW2;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Protein orai-2;
DE   AltName: Full=Transmembrane protein 142B;
GN   Name=ORAI2; Synonyms=TMEM142B; ORFNames=RCJMB04_4k12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC       subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC       current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; AJ719622; CAG31281.1; -; mRNA.
DR   RefSeq; NP_001025881.1; NM_001030710.1.
DR   AlphaFoldDB; Q5ZLW2; -.
DR   SMR; Q5ZLW2; -.
DR   STRING; 9031.ENSGALP00000002837; -.
DR   PaxDb; Q5ZLW2; -.
DR   Ensembl; ENSGALT00000002840; ENSGALP00000002837; ENSGALG00000001837.
DR   GeneID; 417509; -.
DR   KEGG; gga:417509; -.
DR   CTD; 93129; -.
DR   VEuPathDB; HostDB:geneid_417509; -.
DR   eggNOG; KOG4298; Eukaryota.
DR   GeneTree; ENSGT00390000015354; -.
DR   HOGENOM; CLU_062509_1_1_1; -.
DR   InParanoid; Q5ZLW2; -.
DR   OMA; KMSQSGD; -.
DR   PhylomeDB; Q5ZLW2; -.
DR   TreeFam; TF313576; -.
DR   PRO; PR:Q5ZLW2; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000001837; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q5ZLW2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0002115; P:store-operated calcium entry; IBA:GO_Central.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR030034; Orai-2.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   PANTHER; PTHR31501:SF5; PTHR31501:SF5; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Protein orai-2"
FT                   /id="PRO_0000234393"
FT   TRANSMEM        67..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28955 MW;  00C75137592A0AEA CRC64;
     MSSELNVPVD PSTPACCSEP GTKGMDYRDW VRRSYLELVT SNHHSVQALS WRKLYLSRAK
     LKASSRTSAL LSGFAMVAMV EVQLEMQYKY PQMLLIAFSA CTTVLVAVHL FALLISTCIL
     PNVEAVSNIH NLNSISESPH ERMHPYIELA WGFSTVLGIL LFLAEVVLLC WIKFLPVDSI
     LKNDTTTIQK PSGHAGWQAA LVSTIIMVPV GLIFVVFTIH FYRSLVRHKT ERHNREIEEL
     HKLKVQLDGH DRGMQVV