ID   ORAI2_XENLA             Reviewed;         257 AA.
AC   Q6NZI6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein orai-2;
DE   AltName: Full=Transmembrane protein 142B;
GN   Name=orai2; Synonyms=tmem142b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC       subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC       current by synergy with the Ca(2+) sensor, stim1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; BC066119; AAH66119.1; -; mRNA.
DR   RefSeq; NP_001084444.1; NM_001090975.1.
DR   AlphaFoldDB; Q6NZI6; -.
DR   SMR; Q6NZI6; -.
DR   DNASU; 403390; -.
DR   GeneID; 403390; -.
DR   KEGG; xla:403390; -.
DR   CTD; 403390; -.
DR   Xenbase; XB-GENE-962830; orai1.S.
DR   OMA; HERMHVY; -.
DR   OrthoDB; 1197243at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 403390; Expressed in testis and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR030034; Orai-2.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   PANTHER; PTHR31501:SF5; PTHR31501:SF5; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Protein orai-2"
FT                   /id="PRO_0000234394"
FT   TRANSMEM        62..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28928 MW;  C95D435A873BDA7C CRC64;
     MSSELNIPVD PSTPAVSERG NKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL
     KASSRTSALL SGFAMVAMVE VQLEMKYGYP QLLLIAFSAC TTVLVAVHLF ALLISTCILP
     NVEAVSNIHN LNSVNESPHD RMHPYIELAW GFSTALGILL FLAEVVLLCW IKFLPIDSAL
     TRNETATTQK PRGNAGWNSA LVSTIIMVPV GIIFVIFTIH FYRTLVRHKT ERHHQEIEEL
     HKLKVQLDGH DRGINVV