ORAI3_MOUSE
ID ORAI3_MOUSE Reviewed; 290 AA.
AC Q6P8G8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein orai-3;
DE AltName: Full=Transmembrane protein 142C;
GN Name=Orai3; Synonyms=Tmem142c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-45, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC current by synergy with the Ca(2+) sensor, STIM1.
CC {ECO:0000250|UniProtKB:Q9BRQ5}.
CC -!- SUBUNIT: Interacts with CRACR2A/EFCAB4B.
CC {ECO:0000250|UniProtKB:Q9BRQ5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR EMBL; AK136955; BAE23186.1; -; mRNA.
DR EMBL; BC061259; AAH61259.1; -; mRNA.
DR CCDS; CCDS21878.1; -.
DR RefSeq; NP_940816.1; NM_198424.3.
DR AlphaFoldDB; Q6P8G8; -.
DR SMR; Q6P8G8; -.
DR STRING; 10090.ENSMUSP00000050279; -.
DR iPTMnet; Q6P8G8; -.
DR PhosphoSitePlus; Q6P8G8; -.
DR MaxQB; Q6P8G8; -.
DR PaxDb; Q6P8G8; -.
DR PRIDE; Q6P8G8; -.
DR ProteomicsDB; 293848; -.
DR Antibodypedia; 3108; 270 antibodies from 29 providers.
DR Ensembl; ENSMUST00000061587; ENSMUSP00000050279; ENSMUSG00000043964.
DR GeneID; 269999; -.
DR KEGG; mmu:269999; -.
DR UCSC; uc009jwr.1; mouse.
DR CTD; 93129; -.
DR MGI; MGI:3039586; Orai3.
DR VEuPathDB; HostDB:ENSMUSG00000043964; -.
DR eggNOG; KOG4298; Eukaryota.
DR GeneTree; ENSGT00390000015354; -.
DR HOGENOM; CLU_062509_1_1_1; -.
DR InParanoid; Q6P8G8; -.
DR OMA; MASTVIM; -.
DR OrthoDB; 1197243at2759; -.
DR PhylomeDB; Q6P8G8; -.
DR TreeFam; TF313576; -.
DR BioGRID-ORCS; 269999; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q6P8G8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6P8G8; protein.
DR Bgee; ENSMUSG00000043964; Expressed in granulocyte and 181 other tissues.
DR ExpressionAtlas; Q6P8G8; baseline and differential.
DR Genevisible; Q6P8G8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0002115; P:store-operated calcium entry; IMP:MGI.
DR Gene3D; 1.20.140.140; -; 1.
DR InterPro; IPR012446; CRAC_channel.
DR InterPro; IPR030032; Orai-3.
DR InterPro; IPR038350; Orai_sf.
DR PANTHER; PTHR31501; PTHR31501; 1.
DR PANTHER; PTHR31501:SF6; PTHR31501:SF6; 1.
DR Pfam; PF07856; Orai-1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..290
FT /note="Protein orai-3"
FT /id="PRO_0000234396"
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 290 AA; 31358 MW; F702164F9F1EB44B CRC64;
MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS WRRLYLSRAK
LKASSRTSAL LSGFAMVAMV EVQLENDHEY PPGLLVAFSA CTTVLVAVHL FALMVSTCLL
PHIEAVSNIH NLNSVHQSPH QRLHRYVELA WGFSTALGTF LFLAEVVLVG WVKFVPIGAP
MGKPAPVVPM SQVPPVTVSL SLASNLTPSS ASITTSQQPS KACPPRQVCD SAHGPGWQAA
MASTAIMVPV GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV
