ID   ORAI3_RAT               Reviewed;         290 AA.
AC   Q6AXR8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Protein orai-3;
DE   AltName: Full=Transmembrane protein 142C;
GN   Name=Orai3; Synonyms=Tmem142c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC       subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC       current by synergy with the Ca(2+) sensor, STIM1.
CC       {ECO:0000250|UniProtKB:Q9BRQ5}.
CC   -!- SUBUNIT: Interacts with CRACR2A/EFCAB4B.
CC       {ECO:0000250|UniProtKB:Q9BRQ5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; BC079355; AAH79355.1; -; mRNA.
DR   RefSeq; NP_001014046.1; NM_001014024.1.
DR   AlphaFoldDB; Q6AXR8; -.
DR   SMR; Q6AXR8; -.
DR   STRING; 10116.ENSRNOP00000025732; -.
DR   PhosphoSitePlus; Q6AXR8; -.
DR   PaxDb; Q6AXR8; -.
DR   GeneID; 309000; -.
DR   KEGG; rno:309000; -.
DR   UCSC; RGD:1306538; rat.
DR   CTD; 93129; -.
DR   RGD; 1306538; Orai3.
DR   eggNOG; KOG4298; Eukaryota.
DR   HOGENOM; CLU_062509_1_0_1; -.
DR   InParanoid; Q6AXR8; -.
DR   OrthoDB; 1197243at2759; -.
DR   PhylomeDB; Q6AXR8; -.
DR   TreeFam; TF313576; -.
DR   PRO; PR:Q6AXR8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q6AXR8; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0002115; P:store-operated calcium entry; ISO:RGD.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR030032; Orai-3.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   PANTHER; PTHR31501:SF6; PTHR31501:SF6; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..290
FT                   /note="Protein orai-3"
FT                   /id="PRO_0000234397"
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         42
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P8G8"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P8G8"
SQ   SEQUENCE   290 AA;  31311 MW;  6E7F2E8C113BFBE7 CRC64;
     MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS WRRLYLSRAK
     LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA CTTVLVAVHL FALMVSTCLL
     PHIEAVSNIH NLNSVHQSPH QRLHRYVELA WGFSTALGTF LFLAEVVLVG WVKFVPIGAP
     MDKPAPVVPM SQVPPVTVSL SLASNLTPSS ASVATTQQPP KACPPRQVCG SAHGPGWQAA
     MASTAIMVPV GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV