ID   ORAI_CAEBR              Reviewed;         300 AA.
AC   Q616J1; A8XLJ9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein orai;
DE   AltName: Full=Store-operated calcium channel;
GN   Name=orai-1; ORFNames=CBG15255;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel
CC       subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective
CC       current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+)
CC       and IP3-dependent contractile activity of sheath cells and the
CC       spermatheca. Affects brood size and somatic cell function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Orai family. {ECO:0000305}.
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DR   EMBL; HE601055; CAP33503.1; -; Genomic_DNA.
DR   RefSeq; XP_002642971.1; XM_002642925.1.
DR   AlphaFoldDB; Q616J1; -.
DR   SMR; Q616J1; -.
DR   STRING; 6238.CBG15255; -.
DR   EnsemblMetazoa; CBG15255c.1; CBG15255c.1; WBGene00035569.
DR   GeneID; 8584964; -.
DR   KEGG; cbr:CBG_15255; -.
DR   CTD; 8584964; -.
DR   WormBase; CBG15255a; CBP39804; WBGene00035569; Cbr-orai-1.
DR   eggNOG; KOG4298; Eukaryota.
DR   HOGENOM; CLU_940845_0_0_1; -.
DR   InParanoid; Q616J1; -.
DR   OMA; SMNSLRM; -.
DR   OrthoDB; 1197243at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0002115; P:store-operated calcium entry; IBA:GO_Central.
DR   Gene3D; 1.20.140.140; -; 1.
DR   InterPro; IPR012446; CRAC_channel.
DR   InterPro; IPR038350; Orai_sf.
DR   PANTHER; PTHR31501; PTHR31501; 1.
DR   Pfam; PF07856; Orai-1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..300
FT                   /note="Protein orai"
FT                   /id="PRO_0000234387"
FT   TOPO_DOM        1..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..153
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..205
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..300
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          58..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  32800 MW;  AD55730390EFB3AF CRC64;
     MPRSHDPSRV ELLRQEGSTM NEKRVSISVE DIRGAVATWK TTSGAPITPY PLPQFFLQPP
     SSGGGSRNVG GGDGAAGNSK NGSMNSLRMQ AYAKKTDDDV DLGHRGELDL SEKYNYDLSK
     AQLKASSRTS ALLAGFAMVC LVELQYDDST SKPLLIVLGV VTSLLVSVHL LALMMSTCIL
     PYMEATGCTQ DSPHLKLKFY IDLSWLFSTC IGLLLFLVEI GVIFYVKFTA VGYPTAGYIT
     TAMLIPVGIV FVLFSYLIHK NRVSHSLGRF KDKVDTMKQF LDVEANLQKS TIAPSTIRDI