ID   ORA_PLAFN               Reviewed;         701 AA.
AC   P16405;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Octapeptide-repeat antigen;
DE            Short=ORA;
DE   Flags: Fragment;
OS   Plasmodium falciparum (isolate NF7 / Ghana).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5842;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2564637; DOI=10.1016/0166-6851(89)90078-9;
RA   Favaloro J.M., Marshall V.M., Crewther P.E., Coppel R.L., Kemp D.J.,
RA   Anders R.F.;
RT   "cDNA sequence predicting an octapeptide-repeat antigen of Plasmodium
RT   falciparum.";
RL   Mol. Biochem. Parasitol. 32:297-299(1989).
CC   -!- SUBCELLULAR LOCATION: Parasitophorous vacuole {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: In trophozoites, schizonts, and merozoites.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; J04007; AAA29713.1; -; mRNA.
DR   AlphaFoldDB; P16405; -.
DR   SMR; P16405; -.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.12780; -; 2.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Repeat.
FT   CHAIN           <1..>701
FT                   /note="Octapeptide-repeat antigen"
FT                   /id="PRO_0000193178"
FT   REPEAT          653..660
FT                   /note="1"
FT   REPEAT          661..668
FT                   /note="2"
FT   REPEAT          669..676
FT                   /note="3"
FT   REPEAT          677..684
FT                   /note="4"
FT   REPEAT          685..692
FT                   /note="5"
FT   REPEAT          693..700
FT                   /note="6"
FT   REGION          120..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          641..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..700
FT                   /note="6 X 8 AA approximate tandem repeats"
FT   COMPBIAS        642..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..701
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        334
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        477
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        557
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         701
SQ   SEQUENCE   701 AA;  79049 MW;  0E4AB3020011391C CRC64;
     KKVLSFSHSL NTYEGTGVPE KIYNEEKNNG KFRLLGLYGN NSTNWLITDC ACMISGVTTL
     VMHSKFSIDI IIDILNNTKL EWLCLDLDLV EGLLCRKNEL PYLKKLIILD NLTKRSEMKI
     ENEEKSNGSR KSSNKQKYNE SDKREDISLC ALECDKEKIE KINSLKEKAK TLGLSIIVFD
     NMTENKIANV TVQNEDPNFI ASIVYTSGTS GKPKGVMLSN RNLYNGVIPP CDCNIIKKYP
     LTTHLSYLPV SHIYERVIFF IALFLGVKIN IWSRDIKFLN TDICNSKAEI ILGVPKVFNR
     MYATIMTKIN NLSRCKKWIA KQAINLRKGK NNGNFSKVVE GITNISRKIK DKINPNMDVI
     LNGGGKLSPE VAEGLSVLLN VKYYQGYGLT ESTGPIFLQD VDDCNTESMG VAVSPSTRYK
     VRTWEIYKAT DTIPKGELLI KSDSMFSGYF LEKESTEHAF TNDGYFKTGD IVQINDNGSL
     TFLDRSKGLV KLSQGEYIET EMINNLYSQI PFVNFCVAYG DDSMDGPLGI ISVDKHKLFT
     FLKNDNMLKT TGVDEKNFSE KLIDETLNDP IYVDYVKGKM MEIYKKTNLN RYNVINDIYL
     TSKPWDTTNY LTPTLKIRRF NVFKDFSFFI DEVKKKYEEK LSGSSTGSMN NGKSGSKSDI
     KGGSKDDIKS GSKDDIKSGS KADIKSGSKD DIKSGSKDHI K