ID   ORC2_CAEEL              Reviewed;         430 AA.
AC   Q21037;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Origin recognition complex subunit 2;
DE            Short=CeOrc2;
GN   Name=orc-2; ORFNames=F59E10.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7502077; DOI=10.1126/science.270.5242.1667;
RA   Gavin K.A., Hidaka M., Stillman B.D.;
RT   "Conserved initiator proteins in eukaryotes.";
RL   Science 270:1667-1671(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ORC2 family. {ECO:0000305}.
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DR   EMBL; U40270; AAC46954.1; -; mRNA.
DR   EMBL; Z36949; CAA85415.1; -; Genomic_DNA.
DR   PIR; T23001; T23001.
DR   RefSeq; NP_496339.1; NM_063938.4.
DR   AlphaFoldDB; Q21037; -.
DR   SMR; Q21037; -.
DR   BioGRID; 39986; 5.
DR   STRING; 6239.F59E10.1; -.
DR   EPD; Q21037; -.
DR   PaxDb; Q21037; -.
DR   PeptideAtlas; Q21037; -.
DR   EnsemblMetazoa; F59E10.1.1; F59E10.1.1; WBGene00003882.
DR   GeneID; 174676; -.
DR   KEGG; cel:CELE_F59E10.1; -.
DR   UCSC; F59E10.1; c. elegans.
DR   CTD; 174676; -.
DR   WormBase; F59E10.1; CE11492; WBGene00003882; orc-2.
DR   eggNOG; KOG2928; Eukaryota.
DR   GeneTree; ENSGT00390000015228; -.
DR   HOGENOM; CLU_682032_0_0_1; -.
DR   InParanoid; Q21037; -.
DR   OMA; FINVNTM; -.
DR   OrthoDB; 1404162at2759; -.
DR   PhylomeDB; Q21037; -.
DR   Reactome; R-CEL-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-CEL-68949; Orc1 removal from chromatin.
DR   Reactome; R-CEL-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q21037; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003882; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000228; C:nuclear chromosome; IDA:WormBase.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR007220; ORC2.
DR   PANTHER; PTHR14052; PTHR14052; 1.
DR   Pfam; PF04084; ORC2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..430
FT                   /note="Origin recognition complex subunit 2"
FT                   /id="PRO_0000127078"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  49320 MW;  54FC086BB4AD9670 CRC64;
     MPRPKILKRA TVQPSAAVPV KKSTPEKEGS RQKKTNGKEN ASRNLQSNLE EDLEQLGFED
     ETVSMAQSAI ENYFMQGKSA SERMNNAKSR RGRRAGNGNT EEIEEDDEIS NAITDFTKCD
     LPGLRNYITK KDNTEFEKRL EHLADNDFGK WKLYLAAGFN ILLHGVGSKR DVLTEFENEL
     SDYTYMRVDA RKDGLNVKVL LGAINENMKL NCNVKRGQST ISWARSIRRK MNSQQLILII
     DNIEAPDWRS DQEAFCELLE NRDSVKLIAT VDHIYSTFIW NSRQLSSLSF VHITINTFEI
     PLQELMTGDS RLLGLDARSN QSSHTMSSLD VFWKSLAVNS QKLFRLFFQM YFDTKKPVKF
     WDLFNAAKDD FIASTDAALR TQLVEFKDHR VLKWTRGDDG NDQLSGIVEL RLVTEFLESK
     NMPLDEKKDE