ID   ORC2_DICDI              Reviewed;         391 AA.
AC   Q55CU7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Origin recognition complex subunit 2;
DE   AltName: Full=Origin replication complex subunit B;
GN   Name=orcB; Synonyms=orc2; ORFNames=DDB_G0269894;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72297.1; -; Genomic_DNA.
DR   RefSeq; XP_646384.1; XM_641292.1.
DR   AlphaFoldDB; Q55CU7; -.
DR   SMR; Q55CU7; -.
DR   STRING; 44689.DDB0231726; -.
DR   PaxDb; Q55CU7; -.
DR   EnsemblProtists; EAL72297; EAL72297; DDB_G0269894.
DR   GeneID; 8617339; -.
DR   KEGG; ddi:DDB_G0269894; -.
DR   dictyBase; DDB_G0269894; orcB.
DR   eggNOG; KOG2928; Eukaryota.
DR   HOGENOM; CLU_018596_1_0_1; -.
DR   InParanoid; Q55CU7; -.
DR   OMA; FINVNTM; -.
DR   PhylomeDB; Q55CU7; -.
DR   Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-DDI-68689; CDC6 association with the ORC:origin complex.
DR   Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR   Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q55CU7; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR007220; ORC2.
DR   PANTHER; PTHR14052; PTHR14052; 1.
DR   Pfam; PF04084; ORC2; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..391
FT                   /note="Origin recognition complex subunit 2"
FT                   /id="PRO_0000329970"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  44432 MW;  E2BFD5458ABAB747 CRC64;
     MEEYTDSGED KNVYSDDDND YFTASTQNNR TSKNTDSSPL DPKRLAEEMS KIQPKHEKEK
     KKLFESYYKT RENEENGADN HCFKFNKIYT DLKFDYSVLV SGFGSKIQLI ETFVKEFCTD
     GPSLHFKGYL PNLSVRDLLY KITFSLFGID KKIASPIAHC NFIKSIFESG SMDINKMRQT
     FGGRFDYGIP DHVYVVIHNI DGYSLRNETS QLTLALLATI PQVHMIATID AIGAQLLWDN
     RMLSNFNWTT YSMPTYQPYD LELSYDTNTK GGGGGGGIGS KSSSGTNKNL QPSTILTVLK
     SLTEISTDIF KELLTYLIKK KKNKMEFKIL FDICRDAFLV SSESGLKTQL REFIDHKIII
     QKEIGDTTFL IIPIETSVME IILSQLENSI S