ID   A2MGH_NOSS1             Reviewed;        1906 AA.
AC   Q8YM40;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Alpha-2-macroglobulin homolog {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=all5100;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved thioester bond that is characteristic of
CC       the alpha-2-macroglobulins. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000019; BAB76799.1; -; Genomic_DNA.
DR   PIR; AD2443; AD2443.
DR   AlphaFoldDB; Q8YM40; -.
DR   SMR; Q8YM40; -.
DR   STRING; 103690.17134238; -.
DR   DNASU; 1108704; -.
DR   EnsemblBacteria; BAB76799; BAB76799; BAB76799.
DR   KEGG; ana:all5100; -.
DR   eggNOG; COG2373; Bacteria.
DR   OMA; LDRYPYG; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..1906
FT                   /note="Alpha-2-macroglobulin homolog"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000036238"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   1906 AA;  211373 MW;  B73C2F49C63EA92A CRC64;
     MIIRVCIRCF IVLTLVLGIG GCNFFGINSG REPLPAVSPL TPPKLPDWIE QISPIGEAQP
     LNQIRIRFKE ALIPVESLDS PEQQQLLQKF ALWPPLPGQF RFLTPRMVGF QADKALPIAT
     RLQVTLKAGL ADLKNHRLDK DLSWTFNTQS INLTNLPGVN PIEKADAEPI DLQPKLQFTS
     NVELDLASVQ EHLQLIPEGK NEGLRFQVTL NKEEKPLDKE EPLKKFDPSA RNWIYNLRPQ
     KNLKTATRYR LVFSPGIRPA YGNLVTDREF VSKLSTYSPL AFQKINFYGQ PDAGGTYGRF
     IKGSPQLEFN NILVAESAKT NIKINPAPKD ISRLLQVNDE DRIIGINPYA LEPAKTYTIT
     IGENLQDKFG QTLGKPVSLK YDTGDLAGDI WVPSDLNIFP AGKDLRLNIS TVNLPESKYQ
     AAYRVVKPTD LVYFNYGNDL LPKPAEWKSF QVSGKKNQSV DVTVPLREKI NAKTGMLAYG
     VQARTNKYQE NGKELWREPT TYGLVELTNL GVFSQWFPES GLIRVNHLTD GAPVKAAVIE
     IYQSKLQAKS RPEPVPCATG KTDENGTFRV NREALQQCTA GSQNSIKSPE LLVIASEKED
     WAFTRTEEYS GVYGYGIDAG WQGNKPESRG VIFSDRQLYQ SGEKAWFTGF ADYLQNGVIQ
     QDKNADYQIT LVNPDGQKTS LGTQTTNEFG TFSLEMPINK TQGLGYYTIQ AKGKNGLEIS
     GEFRVAEFKP PNFKVEVKLD KEFAYIGDDV DINATSNYLF GAPVEGGEAK YFITRQQANF
     IPKGWEEFTF GRQWFWPEEA PTISSDVLQS NSQLDGNDKS SQMVNVAKDL PYPMTYRVDV
     QVADVSNLSV ANSQSFTALP SNRLIGLKSN FIADAGKAFP IEVIIADPTG KLITGQRVRL
     ELQQIKYSSV TQLVEGSQTP KNQVEYKTVA QTEITSTSNP QSVNLTPPES GTYRIRVNFS
     DAKNELGATD SQIWVTGGNA VFWGTRDKDV LEVKLDKKEY KAGETATALI QSPYADAELY
     FAVIKDKPIY QQITKVQGSA PQIQFRVTPE MLPNAAVEAV LVRQGKPINQ VEVGSLDNLV
     KIGFTPFKVN LEDKYLKLQV KPAQASLEPG AEETIQLEVK DNQGNPTKGQ LTVMVVNEAV
     LQLSGYRPPN LVDTVYAEQP ISTRFTDNRP DVILQPQDVA KPKGWGYGGG FSTGAANTRT
     RTDFQPLAYY NGSVLTDASG NAQITVKLPD DLTTWRVMAV ATDGNLRFGN GDATFITTKP
     LLSNAILPQF VRPGDRILAG LSVTNNTGNT GNLSINGEIS GAVKFNSKNP TTTTLQTQAE
     SATQAYRFPM VADSVGVGKV RFTTQLNGTA DAFELPLQVK PLEITEQIVE TGVSQKQIKI
     PLNVDKNTFP EAGGLDIQLA STLIPEIKAP AKQVLTDNDL PFTEPSASQL IIATNLQTIA
     QKYGQTFAEF NSRQQANLAV EKLQKLQISD GGFAAFPGQE KSDPWVSAYS VESLVKASQV
     FPNLVDTGML SRLKTYLQKV LANPGEYDFC KQQLCKRQLQ LNALIALSEL GDKRNTFLTD
     IYEQRNNFDL VTQIKLARYL SQFPEWQDES QQLVNKLQQN ISETGRTAVV SLPPSWGWMS
     SPTTAQAQAL RLFIAKQSKP EIIDKLLQSL LALRRDGTWQ TDYNNAQALT ALVEYGQLQP
     TPPNFVATVQ LAGRKLGENR FTGYKNPSLQ LSVPMNQLPR GRHDLTLQKS GNGTLHYLVA
     YNYRLQGNQP GRFNGLRITR EISQVNAKRI LRKTGIYALD QPLTLALGQV FDIGLEIIVD
     RPVDHLVIKD PLPAGLEAVD ASFQTTTAAL QAKADSWELG FRNIYSDRII AYADHLEPGV
     YSLHYLVRSV TPGTFSWPGA EVHLQYAPEE FGRTAEMKLI VEEKGR