ORC2_XENLA
ID ORC2_XENLA Reviewed; 558 AA.
AC Q91628;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Origin recognition complex subunit 2;
DE Short=xORC2;
GN Name=orc2; Synonyms=orc2l;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Oocyte;
RX PubMed=8552193; DOI=10.1038/379357a0;
RA Carpenter P.B., Mueller P.R., Dunphy W.G.;
RT "Role for a Xenopus Orc2-related protein in controlling DNA replication.";
RL Nature 379:357-360(1996).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the ORC2 family. {ECO:0000305}.
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DR EMBL; U31984; AAA96391.1; -; mRNA.
DR PIR; S68447; S68447.
DR AlphaFoldDB; Q91628; -.
DR SMR; Q91628; -.
DR IntAct; Q91628; 1.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IDA:CAFA.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR007220; ORC2.
DR PANTHER; PTHR14052; PTHR14052; 1.
DR Pfam; PF04084; ORC2; 1.
PE 2: Evidence at transcript level;
KW DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..558
FT /note="Origin recognition complex subunit 2"
FT /id="PRO_0000127077"
FT REGION 119..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 62927 MW; 7B5383304F6E5082 CRC64;
MSHEAHNGTK LFKVQFTPDE EVLEHITDKQ GVTPQSNTAA QRIVAVKNII KNDDLHVDEA
TPESWREQNY VDVLGVDTED TLQNGPGTGG GDVYSFYTIK RSNKMAQLAT EMARTPAKTV
SFSVSDNPEE AVSPPANKQT ENKTPSKGRK NEFISTTPHR LRKRLSAPSQ PSDSESDYSA
SNSDEELEEK SSAAKTPSKV SQTPGKTPSK KGKKNTASNL VEEYFEAHSS SKVLTSDRTL
QRLQTPKLDQ ETLRKLLDQT PSAFADELHR ISKKHEALFY KWMLQLHLGF NIILFGLGSK
QSLIEKFRTS LLQDSLHIVI NEFFPSITAK SILNSITEEA LGHPGAFRSP LDQMDFILQR
FKDDPSLELY LLIHNLDSQM LRGEKCQQVL GQLASIPNLH LLASVDHINA PLMWDQSKQS
LYNWLWYETT TFGSYIEETS YENSLLVKRS GALALSSLTH VLRSLTPNAR GIFRLLAEYQ
MANKDNPSYT GLSFQDFYQQ CREAFLVNSD LTLRAQLTEF RDHKLIRTKK GMDGVEYLLI
PLDLGTLTDF LEMEDKDT