位置:首页 > 蛋白库 > ORC2_XENLA
ORC2_XENLA
ID   ORC2_XENLA              Reviewed;         558 AA.
AC   Q91628;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Origin recognition complex subunit 2;
DE            Short=xORC2;
GN   Name=orc2; Synonyms=orc2l;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=8552193; DOI=10.1038/379357a0;
RA   Carpenter P.B., Mueller P.R., Dunphy W.G.;
RT   "Role for a Xenopus Orc2-related protein in controlling DNA replication.";
RL   Nature 379:357-360(1996).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication.
CC   -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ORC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U31984; AAA96391.1; -; mRNA.
DR   PIR; S68447; S68447.
DR   AlphaFoldDB; Q91628; -.
DR   SMR; Q91628; -.
DR   IntAct; Q91628; 1.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IDA:CAFA.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR007220; ORC2.
DR   PANTHER; PTHR14052; PTHR14052; 1.
DR   Pfam; PF04084; ORC2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..558
FT                   /note="Origin recognition complex subunit 2"
FT                   /id="PRO_0000127077"
FT   REGION          119..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  62927 MW;  7B5383304F6E5082 CRC64;
     MSHEAHNGTK LFKVQFTPDE EVLEHITDKQ GVTPQSNTAA QRIVAVKNII KNDDLHVDEA
     TPESWREQNY VDVLGVDTED TLQNGPGTGG GDVYSFYTIK RSNKMAQLAT EMARTPAKTV
     SFSVSDNPEE AVSPPANKQT ENKTPSKGRK NEFISTTPHR LRKRLSAPSQ PSDSESDYSA
     SNSDEELEEK SSAAKTPSKV SQTPGKTPSK KGKKNTASNL VEEYFEAHSS SKVLTSDRTL
     QRLQTPKLDQ ETLRKLLDQT PSAFADELHR ISKKHEALFY KWMLQLHLGF NIILFGLGSK
     QSLIEKFRTS LLQDSLHIVI NEFFPSITAK SILNSITEEA LGHPGAFRSP LDQMDFILQR
     FKDDPSLELY LLIHNLDSQM LRGEKCQQVL GQLASIPNLH LLASVDHINA PLMWDQSKQS
     LYNWLWYETT TFGSYIEETS YENSLLVKRS GALALSSLTH VLRSLTPNAR GIFRLLAEYQ
     MANKDNPSYT GLSFQDFYQQ CREAFLVNSD LTLRAQLTEF RDHKLIRTKK GMDGVEYLLI
     PLDLGTLTDF LEMEDKDT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024