ID   ORC3_BOVIN              Reviewed;         712 AA.
AC   Q32PJ3;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Origin recognition complex subunit 3;
GN   Name=ORC3; Synonyms=ORC3L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication. Binds histone H3 and H4 trimethylation
CC       marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase.
CC       {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for
CC       efficient DNA replication origin site activation. Ubiquitination levels
CC       are low in mitotic and early G1-phAse cells and are induced in late
CC       G1-/early S-phase, peaking in S-phase and decrease toward the end of
CC       the cell cycle. {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SIMILARITY: Belongs to the ORC3 family. {ECO:0000305}.
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DR   EMBL; BC108095; AAI08096.1; -; mRNA.
DR   RefSeq; NP_001033228.1; NM_001038139.1.
DR   AlphaFoldDB; Q32PJ3; -.
DR   SMR; Q32PJ3; -.
DR   STRING; 9913.ENSBTAP00000022571; -.
DR   PaxDb; Q32PJ3; -.
DR   PRIDE; Q32PJ3; -.
DR   GeneID; 523714; -.
DR   KEGG; bta:523714; -.
DR   CTD; 23595; -.
DR   eggNOG; KOG2538; Eukaryota.
DR   InParanoid; Q32PJ3; -.
DR   OrthoDB; 1196817at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006275; P:regulation of DNA replication; ISS:UniProtKB.
DR   InterPro; IPR020795; ORC3.
DR   InterPro; IPR045663; ORC3_ins.
DR   InterPro; IPR045667; ORC3_N.
DR   InterPro; IPR040855; ORC_WH_C.
DR   PANTHER; PTHR12748; PTHR12748; 1.
DR   Pfam; PF19675; ORC3_ins; 1.
DR   Pfam; PF07034; ORC3_N; 1.
DR   Pfam; PF18137; ORC_WH_C; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA replication; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..712
FT                   /note="Origin recognition complex subunit 3"
FT                   /id="PRO_0000245348"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
FT   MOD_RES         516
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
SQ   SEQUENCE   712 AA;  82231 MW;  9A823F1548A657AA CRC64;
     MATSSVSKGC FVFKPNFKKR KISVPIEDYF NKGKNASEDS KLRFETYQLI WQQMKSETER
     LQEELNKNLF DSLVEFLQTS HSGLWKNSKD WSCEIKLREI PTAALVLGVN VTDHDLTLRS
     LTEVLQNNVT PYVVSLQAKD CPDMKHFLQK LVSQLMDCKV DVQSKEKESV QVIQKNVHYS
     MDSLSAWYMS VTQKTDPKMP RKKRTSSSQW QSPPVVLILK DMESFTTKVL QDFIIISSQH
     LHEFPLILIF GIATSPVVIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF
     KLSEKVLQIL TNIFLYHDFS IQNFIKGLQL SLLEHFYSQP LSVLCCNLPE AKRRIRFLSA
     NQCENIRRLP SFRRYVEKQS SEKQVALLTS DKFLKEETQS LLENLHVYHK NYFLVLRCLH
     QFTSSLPKYP LGRQIRELYC MCLEKSIWDS EEYASVLQLL RLLAKDELMA MLQNCFKLFQ
     SSSGKELGNT AKRIEEFLAQ FQSLDETKEE EDTSQSQSKG LQKTDLYHLQ KSLLEMKELR
     STSKRQTKFE VLREQVVSFV DSLVREYLLP PDTQPLHETL YFSSAHTLRQ HLNAAPRIAL
     HTALNNPYYY LKNEALRSEE GCIPNVAPDI CIAYKLHLEC SRLINLVDWS EAFATVVTAA
     EKMDANSVTS GERNEIIHAR FIRAVSELEL LGFIKPTKQK TDHVARLTWG GC