ORC3_DICDI
ID ORC3_DICDI Reviewed; 1080 AA.
AC Q55BR6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Origin recognition complex subunit 3;
DE AltName: Full=Origin replication complex subunit C;
GN Name=orcC; Synonyms=orc3; ORFNames=DDB_G0271078;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ORC3 family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72889.2; -; Genomic_DNA.
DR RefSeq; XP_646765.2; XM_641673.2.
DR AlphaFoldDB; Q55BR6; -.
DR STRING; 44689.DDB0233773; -.
DR PaxDb; Q55BR6; -.
DR PRIDE; Q55BR6; -.
DR EnsemblProtists; EAL72889; EAL72889; DDB_G0271078.
DR GeneID; 8617738; -.
DR KEGG; ddi:DDB_G0271078; -.
DR dictyBase; DDB_G0271078; orcC.
DR eggNOG; KOG2538; Eukaryota.
DR HOGENOM; CLU_286273_0_0_1; -.
DR InParanoid; Q55BR6; -.
DR OMA; FEDLSRW; -.
DR Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-DDI-68689; CDC6 association with the ORC:origin complex.
DR Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR PRO; PR:Q55BR6; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR InterPro; IPR020795; ORC3.
DR InterPro; IPR045667; ORC3_N.
DR InterPro; IPR040855; ORC_WH_C.
DR PANTHER; PTHR12748; PTHR12748; 1.
DR Pfam; PF07034; ORC3_N; 1.
DR Pfam; PF18137; ORC_WH_C; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..1080
FT /note="Origin recognition complex subunit 3"
FT /id="PRO_0000329969"
FT REGION 92..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1080 AA; 125199 MW; A4E6C02E648B4335 CRC64;
MAGENYCSVC EGIISTENDL AVCYKCKEEI FHKACGKKVF DSLRCLNCGP IEKRSLSHQI
GEISKGKAKL ETRTSRFTGI NVTKEFIESG EYGISKGDDD DDGDYVGGDD SSSDDEYFGN
PTVLNNYPTT MNNVDLNFPT FFLLNEDMKK RKQKIKEDGN NEEIKKIEQE EKMIIQEYQN
EEILKFFGDR SCFKQTQLAY EAMVQCLKDL KESIERMFKV VSVKTLGDIS SFISMSYPKK
SLLDIRDIAL ELIGQSIDDS IHHIPTSILY TSSSSPEVAQ LFQSVPSNVM MRIKSHQPFS
SDISSHLCEP PTITLNPDCC NTFKSTVSTI CHSLTKDYDV TKFPSPHFED LSRWYSNYFS
IPLIQEVIEL FKQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QKDKLEEIML VRTPVILVIE
DFETWNSEVL SDLIHLLSAY RHRIPFVLSF SISTSADAIH KVLPYQVVSL LNLKSLHLRS
QNEMFEQLVK HLFLKSQPYI ISKKAYLYLY YNFKNSYMSL STTISVLRHF IIDHFLENGL
SYLTLDLSNF QIDLKDDDDD MDGCSTIKLE PENDSTDSTV NDEVGTGDNI DNDNVSTHGE
EDTPDSLVKS DIECQTLSYS SDDERNDYDT STDSDNCSNF HKKKPNSNNR IKSDLECNDN
DKDNDDNDND INENNNNINN NNNNNSNNDD NDKDSFGPKR IPNQRFVTLI QKLPSLNTDE
IENSKISTNR KLNKLQSNLI IFKESRPIML ELYYTILSKF QKSKTLKYSE LLKKISLNDR
KSYETLRKTI LTNPESKQSI ETLLDLLKTS RHHFERIIKA TNSLKLFQTP KSKKYQDLVK
IENLILKCRT LSNNFKNLLL PPDEQSKSIK NEIKQQQQQQ QQQQQQQQQQ QHQQQQKIEN
EQKNWSIKKK REHQLRNIQK PTDSYFKIYS REFLDDIVSV IIEDYLYPPL VSVPLSEIFD
FTQTVFITQS RFNFHTAEGI NDNLIHSVRK LKCECCIDSL CGTMDDFSIS FILLLRSGRY
INYFDWLTSF CSIINGDNNP TPNLKARFIK SVDTFVSLEL IKKTRKRKDH FEKIAFLTTS
