ORC3_ORYSJ
ID ORC3_ORYSJ Reviewed; 718 AA.
AC Q0IY07; A0A0P0XU99; B9G5M5; Q338H8; Q852Q8; Q8LND7;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Origin of replication complex subunit 3 {ECO:0000303|PubMed:15939553};
DE Short=OsORC3 {ECO:0000303|PubMed:16100779};
GN Name=ORC3 {ECO:0000303|PubMed:15939553};
GN OrderedLocusNames=LOC_Os10g26280 {ECO:0000305}, Os10g0402200 {ECO:0000305};
GN ORFNames=OsJ_31450 {ECO:0000312|EMBL:EEE50922.1},
GN OSJNBa0044A10.12 {ECO:0000312|EMBL:AAM74272.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000312|Proteomes:UP000059680};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY SUCROSE, TISSUE SPECIFICITY, GENE
RP FAMILY, AND NOMENCLATURE.
RX PubMed=15939553; DOI=10.1016/j.gene.2005.03.047;
RA Mori Y., Yamamoto T., Sakaguchi N., Ishibashi T., Furukawa T., Kadota Y.,
RA Kuchitsu K., Hashimoto J., Kimura S., Sakaguchi K.;
RT "Characterization of the origin recognition complex (ORC) from a higher
RT plant, rice (Oryza sativa L.).";
RL Gene 353:23-30(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP REVIEW ON THE CORE DNA REPLICATION MACHINERY.
RX PubMed=17556508; DOI=10.1104/pp.107.101105;
RA Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT "Genome-wide analysis of the core DNA replication machinery in the higher
RT plants Arabidopsis and rice.";
RL Plant Physiol. 144:1697-1714(2007).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC sequences that define origins of replication have not been identified
CC yet. {ECO:0000250|UniProtKB:Q9UBD5}.
CC -!- SUBUNIT: Component of the origin recognition complex (ORC) composed of
CC at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a
CC cell-cycle and development dependent manner. It is sequentially
CC assembled at the exit from anaphase of mitosis and disassembled as
CC cells enter S phase. {ECO:0000250|UniProtKB:Q6E7H0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in the shoot apical
CC meristem (SAM), leaves, ears and roots (including root tips).
CC {ECO:0000269|PubMed:15939553}.
CC -!- INDUCTION: Reduced expression upon sucrose depletion-mediated cell
CC proliferation arrest, and accumulates after sucrose treatment.
CC {ECO:0000269|PubMed:15939553}.
CC -!- SIMILARITY: Belongs to the ORC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM74272.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABB47555.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE50922.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB100408; BAC56110.1; -; mRNA.
DR EMBL; AC083943; AAM74272.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DP000086; ABB47555.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008216; BAF26464.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT10748.1; -; Genomic_DNA.
DR EMBL; CM000147; EEE50922.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015613475.1; XM_015757989.1.
DR AlphaFoldDB; Q0IY07; -.
DR SMR; Q0IY07; -.
DR STRING; 4530.OS10T0402200-00; -.
DR PaxDb; Q0IY07; -.
DR PRIDE; Q0IY07; -.
DR EnsemblPlants; Os10t0402200-01; Os10t0402200-01; Os10g0402200.
DR GeneID; 4348571; -.
DR Gramene; Os10t0402200-01; Os10t0402200-01; Os10g0402200.
DR KEGG; osa:4348571; -.
DR eggNOG; KOG2538; Eukaryota.
DR HOGENOM; CLU_010669_0_0_1; -.
DR InParanoid; Q0IY07; -.
DR OMA; HLECGRM; -.
DR OrthoDB; 1196817at2759; -.
DR PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000007752; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR Genevisible; Q0IY07; OS.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0048527; P:lateral root development; IMP:CACAO.
DR GO; GO:0009744; P:response to sucrose; IDA:UniProtKB.
DR InterPro; IPR020795; ORC3.
DR InterPro; IPR045667; ORC3_N.
DR InterPro; IPR040855; ORC_WH_C.
DR PANTHER; PTHR12748; PTHR12748; 1.
DR Pfam; PF07034; ORC3_N; 2.
DR Pfam; PF18137; ORC_WH_C; 1.
PE 2: Evidence at transcript level;
KW DNA replication; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..718
FT /note="Origin of replication complex subunit 3"
FT /id="PRO_0000431432"
FT REGION 26..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 659..666
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 27..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 177
FT /note="L -> V (in Ref. 1; BAC56110)"
FT /evidence="ECO:0000305"
FT CONFLICT 288
FT /note="D -> A (in Ref. 1; BAC56110)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="V -> A (in Ref. 1; BAC56110)"
FT /evidence="ECO:0000305"
FT CONFLICT 619
FT /note="L -> S (in Ref. 1; BAC56110)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 718 AA; 80123 MW; 195EE2EDC9571FA4 CRC64;
MAAPPGEAPL TAATNIEPFY VLHKGGAAAS SSSSSAPSLP SSGRARRRID VSGLASPNPK
PGKRSRDDDA AEDDDDDELY ERLRLDAFHR VWSKIQSTIN EVLRGISLKL FDQVLRWVQE
SFSAVRSIAR PSAAEVRQPY PLLTDVICRK IPTAFVLTKN AEFVDDITTF RDLAEYLESN
GCHLAKLSAT ELSEKNGVGC CFRSLLRQLL SDVPDVADIF ALASWYSAAE NYDQPIVVVI
DDLEQCSGDV LGELVMMLSE WVIKIPIFFV MGIATTLDAP RKLLSSEDLQ RLEPCKLTLG
SPSDRMNALV EAILVKPCAG FCISHEVAVF LRNYFFKHDG TITSFISALK LACSKHFSVE
PLSFLCMGML EEDRENFWHD KFNALPQELR KYASGLPSCT REKDSTKSGD NMVDGLSELM
NIQKDWSSVL LCLYEAGKHG KVQLLDIFCE AVNPDLHTQK APNLPNEKSG TSRRFIDQVM
DTIRYLPVET LFCLLEVWSI HLNGMDKITN KVKELQSTTI STDSVRITKD KWPRRSTNST
GNSTVALNDK VAMLLDDVTR KFLVSVECLP FHEIVCFKNV SILQSALIGN PRRMVQLDLV
KSHKHLKCSC CRKNGIAVLA SMHDTSIMCN LAQEYGDVIN LHDWYISFDG IINSVHSKIK
RKPHTSPSKK KSKPVAAESE AMIQARFCRA VTELQITGLL RMPSKRRPDL VQRIAFGL
