ID   ORC3_RAT                Reviewed;         711 AA.
AC   Q4R180;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Origin recognition complex subunit 3;
GN   Name=Orc3; Synonyms=Orc3l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Saitoh Y.;
RT   "Rat origin recognition complex, subunit 3.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication. Binds histone H3 and H4 trimethylation
CC       marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase.
CC       {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for
CC       efficient DNA replication origin site activation. Ubiquitination levels
CC       are low in mitotic and early G1-phAse cells and are induced in late
CC       G1-/early S-phase, peaking in S-phase and decrease toward the end of
CC       the cell cycle. {ECO:0000250|UniProtKB:Q9UBD5}.
CC   -!- SIMILARITY: Belongs to the ORC3 family. {ECO:0000305}.
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DR   EMBL; AB219142; BAE02662.1; -; mRNA.
DR   RefSeq; NP_001020453.1; NM_001025282.1.
DR   AlphaFoldDB; Q4R180; -.
DR   SMR; Q4R180; -.
DR   STRING; 10116.ENSRNOP00000011085; -.
DR   PaxDb; Q4R180; -.
DR   PRIDE; Q4R180; -.
DR   GeneID; 313138; -.
DR   KEGG; rno:313138; -.
DR   UCSC; RGD:1308457; rat.
DR   CTD; 23595; -.
DR   RGD; 1308457; Orc3.
DR   eggNOG; KOG2538; Eukaryota.
DR   InParanoid; Q4R180; -.
DR   OrthoDB; 1196817at2759; -.
DR   PhylomeDB; Q4R180; -.
DR   Reactome; R-RNO-176187; Activation of ATR in response to replication stress.
DR   Reactome; R-RNO-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-RNO-68689; CDC6 association with the ORC:origin complex.
DR   Reactome; R-RNO-68949; Orc1 removal from chromatin.
DR   Reactome; R-RNO-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q4R180; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0000808; C:origin recognition complex; ISO:RGD.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0061351; P:neural precursor cell proliferation; ISO:RGD.
DR   GO; GO:0006275; P:regulation of DNA replication; ISS:UniProtKB.
DR   InterPro; IPR020795; ORC3.
DR   InterPro; IPR045663; ORC3_ins.
DR   InterPro; IPR045667; ORC3_N.
DR   InterPro; IPR040855; ORC_WH_C.
DR   PANTHER; PTHR12748; PTHR12748; 1.
DR   Pfam; PF19675; ORC3_ins; 1.
DR   Pfam; PF07034; ORC3_N; 1.
DR   Pfam; PF18137; ORC_WH_C; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA replication; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..711
FT                   /note="Origin recognition complex subunit 3"
FT                   /id="PRO_0000329971"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
FT   MOD_RES         515
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
SQ   SEQUENCE   711 AA;  81901 MW;  D5D8B3EB087027AA CRC64;
     MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL WQRIKSETEQ
     LQEGLNENLF DNLVDFLQKS HSEFQKNSGN WGSQMRLREI PTAALILGVN VTDHDVIFRS
     LTETLHNNVT PYVVSLQAKD CPDVKHFLQK LTSELIDCCV DRNSKEEKND KALRRTSYSM
     DSLSSWYSTV AQKTGPKMTS KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL
     HEFPLILIFG IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK
     LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA KKRINVFSVN
     QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL LEDLHVYHIN YFLVLRCLHN
     FTSSLPKYPL GRQIRELYCT CLEKKIWDSE EYESALQLLR MLAKDELMGI LEQCVKVLNS
     STEKQLSNTA QKIKGFLTQF QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR
     TTKKPTKFEM LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH
     TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE AFATVVTAAE
     KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT DHVARLTWGG C