ID   ORC3_SPECI              Reviewed;         713 AA.
AC   Q5DJU3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Origin recognition complex subunit 3;
GN   Name=ORC3; Synonyms=ORC3L;
OS   Spermophilus citellus (European suslik) (Citellus citellus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Spermophilus.
OX   NCBI_TaxID=9997;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Stieler J.T., Bruckner M.K., Strijkstra A.M.;
RT   "Molecular cloning of origin recognition complex (ORC3) of Spermophilus
RT   citellus.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication (By similarity). Binds histone H3 and H4
CC       trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC3 family. {ECO:0000305}.
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DR   EMBL; AY743329; AAV59465.1; -; mRNA.
DR   AlphaFoldDB; Q5DJU3; -.
DR   SMR; Q5DJU3; -.
DR   PRIDE; Q5DJU3; -.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR020795; ORC3.
DR   InterPro; IPR045663; ORC3_ins.
DR   InterPro; IPR045667; ORC3_N.
DR   InterPro; IPR040855; ORC_WH_C.
DR   PANTHER; PTHR12748; PTHR12748; 1.
DR   Pfam; PF19675; ORC3_ins; 1.
DR   Pfam; PF07034; ORC3_N; 1.
DR   Pfam; PF18137; ORC_WH_C; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Phosphoprotein.
FT   CHAIN           1..713
FT                   /note="Origin recognition complex subunit 3"
FT                   /id="PRO_0000250499"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
FT   MOD_RES         517
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBD5"
SQ   SEQUENCE   713 AA;  82311 MW;  1B2A547F419E938C CRC64;
     MATSSVSKGC FVFKPNFKKR KISVPIEDYF NKGKNESEDS KLRFETYHLM WEQMKCETER
     LQEELNKNLF DSLIEFLQKS HTGFKKNSGD WGHQIKHREI PVAALVLGVN VTDHDLIFRS
     LTEALQNNVT PYVVSLQAKD CPDMKHFLQK LISQLMACCV DAKPKEKESI QVTQKMTHCS
     MDPLSSWYMT VTQKTHPKIS GKKRTTSSKW QSPPVVLILK DMESFTTKIL QDFIIISSQH
     LHEFPLILIF GIATSPIIIH RLLPHAVSSL LCIELFQSLP CKEHLTTVLD KLLLTAQFPF
     KISEKVLQIL TNIFLYHDFS IQNFVKGLQL SLLEHFYSQP LSVLCCSLPE AKRRINFLSA
     HQCENIRRLP SFRRYVEKQV SEKQVALLTN ERFLKEETQS LLENLHVYHT NYFLVLRCLH
     NFTSSLPKYP LGRQIRELYC TCLEKNIWDS EEYASALQLL RMLARDDLMT ILQKCFKVFK
     SSSEKQLGST AKRIEEFLAQ FQSLDADAKE EEDASGSQPK GLQKTDLYHL QKSLLEMKEL
     RRTSKKQTRF EVLREKVVNF IDCLVREYLL PPETQPLHEV VYFSAAHTLR EHLNAAPRIA
     LHTALNDPYF YIKNEALKSE EGCIPNIAPD ICIAYKLHLE CSRLINLVDW SEAFATVVTA
     AEKMESNSAT TEEMNEIIHA RFIRAVSELE LLGFIKPTKQ KTDHVARLTW GGC