ID   ORC4_BOVIN              Reviewed;         436 AA.
AC   Q2YDI2;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Origin recognition complex subunit 4;
GN   Name=ORC4; Synonyms=ORC4L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication. Binds histone H3 and H4 trimethylation
CC       marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase (By
CC       similarity). Interacts with DBF4 (By similarity). Interacts with POLQ
CC       (By similarity). {ECO:0000250|UniProtKB:O43929,
CC       ECO:0000250|UniProtKB:O88708}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000305}.
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DR   EMBL; BC110211; AAI10212.1; -; mRNA.
DR   RefSeq; NP_001039766.1; NM_001046301.2.
DR   RefSeq; XP_005202501.1; XM_005202444.3.
DR   AlphaFoldDB; Q2YDI2; -.
DR   SMR; Q2YDI2; -.
DR   STRING; 9913.ENSBTAP00000020335; -.
DR   PaxDb; Q2YDI2; -.
DR   PRIDE; Q2YDI2; -.
DR   Ensembl; ENSBTAT00000079417; ENSBTAP00000058035; ENSBTAG00000015291.
DR   GeneID; 529245; -.
DR   KEGG; bta:529245; -.
DR   CTD; 5000; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015291; -.
DR   VGNC; VGNC:32449; ORC4.
DR   eggNOG; KOG2228; Eukaryota.
DR   GeneTree; ENSGT00390000016542; -.
DR   HOGENOM; CLU_007115_0_1_1; -.
DR   InParanoid; Q2YDI2; -.
DR   OrthoDB; 1543398at2759; -.
DR   TreeFam; TF101094; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000015291; Expressed in oocyte and 109 other tissues.
DR   ExpressionAtlas; Q2YDI2; baseline and differential.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; ISS:UniProtKB.
DR   GO; GO:0006270; P:DNA replication initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; PTHR12087; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA replication; DNA-binding; Methylation; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..436
FT                   /note="Origin recognition complex subunit 4"
FT                   /id="PRO_0000245349"
FT   BINDING         67..74
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         7
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O43929"
SQ   SEQUENCE   436 AA;  50327 MW;  92C736F896FB3AE3 CRC64;
     MSSRKSKSSN LIQADYISQV QRILRERFCH QSPHGNLFGV QVQYKHLIEL LKRTAIHGES
     NSILIIGPRG SGKTMLINHA LKELMEIEGV SENILQVHLN GLLQINDKIA LKEITRQLNL
     ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLLDIS
     QSAQTPVVII GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FSFPQYLKIF KEQLSLPSVF
     PEEIFAEKWN ENVQSLSEDR SVKEVLQKHF NVSKNLRSLH MLLMLALNRV TPSHPFITAA
     DLMEANQLCS MDSKGNIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK
     AHSVYNFEKP VVMKAFEHLQ QLELIRPMER TSVNAQREYQ LMKLLLDNTQ IMNALQKYPN
     CPTDVRQWAT SSLSWL