ID   ORC4_CRIGR              Reviewed;         436 AA.
AC   Q4U3P8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Origin recognition complex subunit 4;
GN   Name=ORC4; Synonyms=ORC4L;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15950218; DOI=10.1016/j.yexcr.2005.05.009;
RA   McNairn A.J., Okuno Y., Misteli T., Gilbert D.M.;
RT   "Chinese hamster ORC subunits dynamically associate with chromatin
RT   throughout the cell-cycle.";
RL   Exp. Cell Res. 308:345-356(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Alexandrow M.G., Cao T.V., Zaika E., Hamlin J.L.;
RT   "Cloning and analysis of the Chinese hamster Orc4 and Orc5 subunits reveals
RT   distinct forms of regulation.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication. Binds histone H3 and H4 trimethylation
CC       marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase (By
CC       similarity). Interacts with DBF4 (By similarity). Interacts with POLQ
CC       (By similarity). {ECO:0000250|UniProtKB:O43929,
CC       ECO:0000250|UniProtKB:O88708}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000305}.
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DR   EMBL; AB183827; BAE16571.1; -; mRNA.
DR   EMBL; DQ016321; AAY41171.1; -; mRNA.
DR   RefSeq; NP_001258354.1; NM_001271425.1.
DR   RefSeq; XP_007646934.1; XM_007648744.2.
DR   RefSeq; XP_007646937.1; XM_007648747.2.
DR   AlphaFoldDB; Q4U3P8; -.
DR   SMR; Q4U3P8; -.
DR   STRING; 10029.XP_007646935.1; -.
DR   PRIDE; Q4U3P8; -.
DR   GeneID; 100689043; -.
DR   KEGG; cge:100689043; -.
DR   CTD; 5000; -.
DR   eggNOG; KOG2228; Eukaryota.
DR   OMA; KVSTTMQ; -.
DR   OrthoDB; 1543398at2759; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; ISS:UniProtKB.
DR   GO; GO:0006270; P:DNA replication initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; PTHR12087; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA replication; DNA-binding; Methylation; Nucleotide-binding;
KW   Nucleus.
FT   CHAIN           1..436
FT                   /note="Origin recognition complex subunit 4"
FT                   /id="PRO_0000328609"
FT   BINDING         67..74
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         7
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O43929"
SQ   SEQUENCE   436 AA;  50374 MW;  B164579C049743DC CRC64;
     MSNRKTKGNS AVHPECLSQV QRILRERFCH QSPHSNLFGV QVQYKHLIEL LKRTAINGES
     NSVLIVGPRG SGKTMLINHA LKELMEIREV SENVLQVHLN GLMQINDKIA LTEITRQLNL
     ENVVGDKVFG SFAENLSFLL EALKKGNRAN SCPVIFILDE FDLFAHQKNQ TLLYNLFDIS
     QSAQTPVAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FDFPQYMKIF KEQLSLPEEF
     PNKVFAERWN ENTQSLSEDS TVREVLQKLF NVNKSLRSLH MLLMLALNRV TVSHPFMTSA
     DLMEAQHLCS LDSKASIIHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFIQRK
     AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSVNSQREYQ LVKLLLDNTQ IMNALQKYSN
     CPTDVRQWAT SSLSWL