ID   ORC4_DICDI              Reviewed;         440 AA.
AC   Q86AD6; Q55AT0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Origin recognition complex subunit 4;
DE   AltName: Full=Origin replication complex subunit D;
GN   Name=orcD; Synonyms=orc4; ORFNames=DDB_G0271562;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71645.1; -; Genomic_DNA.
DR   RefSeq; XP_645616.1; XM_640524.1.
DR   AlphaFoldDB; Q86AD6; -.
DR   SMR; Q86AD6; -.
DR   STRING; 44689.DDB0233111; -.
DR   PaxDb; Q86AD6; -.
DR   EnsemblProtists; EAL71645; EAL71645; DDB_G0271562.
DR   GeneID; 8618071; -.
DR   KEGG; ddi:DDB_G0271562; -.
DR   dictyBase; DDB_G0271562; orcD.
DR   eggNOG; KOG2228; Eukaryota.
DR   HOGENOM; CLU_623218_0_0_1; -.
DR   InParanoid; Q86AD6; -.
DR   OMA; KVSTTMQ; -.
DR   PhylomeDB; Q86AD6; -.
DR   Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-DDI-68689; CDC6 association with the ORC:origin complex.
DR   Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR   Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q86AD6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; ISS:UniProtKB.
DR   GO; GO:0006270; P:DNA replication initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; PTHR12087; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..440
FT                   /note="Origin recognition complex subunit 4"
FT                   /id="PRO_0000328602"
FT   BINDING         64..71
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  50744 MW;  D354C82E6BE84579 CRC64;
     MSNIDETENQ EYLLLKAKNI ITERTQSSYL PDEYIGAEKE AETLYAILDD AIINKKSTVG
     LITGPKGSGK SSFFKHCLKK YNESDYLLVR LSGMIHFNDN YALKEIAKAL GIKIPSGLNI
     FHTFEFIRVK LGKETLESQI NTSTKKIQFQ SLPVVILIEE LELMLTSLST SKQSLFYNLL
     DLSHYKNVSL SFIATTSQHD IVNMFEKRIK SRFTQESIKI PPLSFDSIQI IFKNLISLPE
     SFDDEEYRDT WNANVEKSLK STSVIENFKK YYRLYNRVNN YHLLVNEIID NLDYYDKDNK
     WINSKIINDG FEYLNQDVIE IMLKSLSVLE FTILGCILNT KVGTNINDDY ITFDELYDGE
     YKKLSYSFFK NVDQAKKPST IRILQHLLLL GIIKTQSRAN DSGDFPKFKI AIDPDSIINA
     AKNRNDLPTV IVKYVTEWLT